Tumor-associated macrophages (TAMs) represent one of the main tumor-infiltrating immune
cell types and are generally categorized into either of two functionally contrasting subtypes …

Malignant mesothelioma is a universally lethal cancer that is increasing in incidence
worldwide. There is a dearth of effective therapies, with only one treatment (pemetrexed and …

Malignant pleural effusion (MPE) is indicative of terminal malignancy with a uniformly fatal
prognosis. Often, two distinct compartments of tumour microenvironment, the effusion and …

Over the past decade, immune-checkpoint inhibitors (ICIs) have revolutionized the treatment
of cancer. In mesothelioma, a rare cancer with a dismal prognosis generally caused by …

New immunotherapeutic strategies are needed to induce effective antitumor immunity in all
cancer patients. Malignant mesothelioma is characterized by a poor prognosis and …

Abstract Ethnopharmacological relevance Cucurbitacin B (CuB), extracted from muskmelon
pedicel, is a widely available triterpenoid molecule that exerts influence on various …

Macrophages infiltrating tumour tissues or residing in the microenvironment of solid tumours
are known as tumour-associated macrophages (TAMs). These specialized immune cells …

Although mesothelioma is the consequence of a protracted immune response to asbestos
fibers and characterized by a clear immune infiltrate, novel immunotherapy approaches …

The tumor microenvironment (TM) contains a wide variety of cell types and soluble factors
capable of suppressing immune responses. While the presence of NK cells in pleural …

Defining the ontogeny of tumor-associated macrophages (TAM) is important to develop
therapeutic targets for mesothelioma. We identified two distinct macrophage populations in …