Fibril formation implies the conversion of a protein's native secondary structure and is
associated with several neurodegenerative diseases. A better understanding of fibrillation …

The effect of two widely used polyphenols, curcumin and EGCG was investigated on the
amyloid fibrillogenesis of the well-characterized model protein human lysozyme (HuL) …

Ordered fibrillar aggregates of proteins, called amyloids, are prevalent in several diseases
like Alzheimer's, Parkinson's, and Type II diabetes. The key challenge in the treatment of …

Amyloids are proteinaceous deposits considered an underlying pathological hallmark of
several degenerative diseases. The mechanism of amyloid formation and its inhibition still …

One of the main characteristics of biomolecular ions in mass spectrometry is their net
charge, and a range of approaches exist to either increase or decrease this quantity in the …

One of the major problems caused by repeated subcutaneous insulin injections in patients
with diabetes is insulin amyloidosis. Understanding the molecular mechanism of amyloid …

Curcumin as the biologic active of turmeric has many biological properties such as anti-
inflammatory, anti-oxidant, anti-diabetic and anti-cancer activities. Although poor solubility of …

Insulin, a peptide hormone and a key regulator of blood glucose level, is routinely
administered to type-I diabetic patients to achieve the required glycemic control. Insulin …

Amyloid fibrils are characteristic of several disorders including Alzheimer's disease (AD),
with no cure or preventive therapy. Diminishing amyloid deposits using aromatic compounds …

Among foods, the use of plant derivatives as promising drugs and/or excipients has been
considered from various perspectives. In the present study, curcumin, which is one of the …