Recovery from disorders of consciousness: mechanisms, prognosis and emerging therapies

BL Edlow, J Claassen, ND Schiff… - Nature Reviews Neurology, 2021 - nature.com
Substantial progress has been made over the past two decades in detecting, predicting and
promoting recovery of consciousness in patients with disorders of consciousness (DoC) …

Are the neural correlates of consciousness in the front or in the back of the cerebral cortex? Clinical and neuroimaging evidence

M Boly, M Massimini, N Tsuchiya… - Journal of …, 2017 - Soc Neuroscience
The role of the frontal cortex in consciousness remains a matter of debate. In this
Perspective, we will critically review the clinical and neuroimaging evidence for the …

European Academy of Neurology guideline on the diagnosis of coma and other disorders of consciousness

D Kondziella, A Bender, K Diserens… - European journal of …, 2020 - Wiley Online Library
Background and purpose Patients with acquired brain injury and acute or prolonged
disorders of consciousness (DoC) are challenging. Evidence to support diagnostic decisions …

Human consciousness is supported by dynamic complex patterns of brain signal coordination

A Demertzi, E Tagliazucchi, S Dehaene, G Deco… - Science …, 2019 - science.org
Adopting the framework of brain dynamics as a cornerstone of human consciousness, we
determined whether dynamic signal coordination provides specific and generalizable …

Robust EEG-based cross-site and cross-protocol classification of states of consciousness

DA Engemann, F Raimondo, JR King, B Rohaut… - Brain, 2018 - academic.oup.com
Determining the state of consciousness in patients with disorders of consciousness is a
challenging practical and theoretical problem. Recent findings suggest that multiple markers …

[HTML][HTML] What have we really learned from functional connectivity in clinical populations?

J Zhang, A Kucyi, J Raya, AN Nielsen, JS Nomi… - NeuroImage, 2021 - Elsevier
Functional connectivity (FC), or the statistical interdependence of blood-oxygen dependent
level (BOLD) signals between brain regions using fMRI, has emerged as a widely used tool …

Brain networks predict metabolism, diagnosis and prognosis at the bedside in disorders of consciousness

S Chennu, J Annen, S Wannez, A Thibaut, C Chatelle… - Brain, 2017 - academic.oup.com
Recent advances in functional neuroimaging have demonstrated novel potential for
informing diagnosis and prognosis in the unresponsive wakeful syndrome and minimally …

Therapies to restore consciousness in patients with severe brain injuries: a gap analysis and future directions

BL Edlow, LRD Sanz, L Polizzotto, N Pouratian… - Neurocritical care, 2021 - Springer
Abstract Background/Objective For patients with disorders of consciousness (DoC) and their
families, the search for new therapies has been a source of hope and frustration. Almost all …

Neural correlates of consciousness in patients who have emerged from a minimally conscious state: a cross-sectional multimodal imaging study

C Di Perri, MA Bahri, E Amico, A Thibaut… - The Lancet …, 2016 - thelancet.com
Background Between pathologically impaired consciousness and normal consciousness
exists a scarcely researched transition zone, referred to as emergence from minimally …

Neuronal connected burst cascades bridge macroscale adaptive signatures across arousal states

BR Munn, EJ Müller, V Medel, SL Naismith… - Nature …, 2023 - nature.com
The human brain displays a rich repertoire of states that emerge from the microscopic
interactions of cortical and subcortical neurons. Difficulties inherent within large-scale …