Hypoxia, a feature common to most solid tumors, is known to regulate many aspects of
tumorigenesis. Recently, it was suggested that hypoxia increased the size of the cancer …

Abstract HYD-PEP06, an endostatin-modified polypeptide, has been shown to produce
effective anti-colorectal carcinoma effects through inhibiting epithelial–mesenchymal …

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths,
characterized by highly hypoxic tumor microenvironment. Hypoxia-inducible factor-1α (HIF …

The effect of proton pump inhibitor (PPI) on cancer risk has received much attention recently.
In this study, we investigated the mechanism underlying multidrug resistance and the effect …

The hepatic lobule is divided into three zones along the portal-central vein axis. Hepatocytes
within each zone exhibit a distinctive gene expression profile that coordinates their …

Abstract Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that consists of two
subunits, the HIF-1α and HIF-1β (ARNT). Under hypoxic conditions, HIF-1 is an adaptive …

Background The sperm-associated antigen 5 (SPAG5) plays a key role in controlling various
cellular phenomena, including cell cycle progression and proliferation. However, the role of …

ATP-binding cassette (ABC) transporters mediate multidrug resistance and cancer stem cell
properties in various model systems. Yet, their biological significance in cancers, especially …

Although sorafenib is currently used as a standard treatment for advanced hepatocellular
carcinoma, low response rate, transient and limited efficacy, primary and acquired …

Hypoxia can lead to different responses from cancer cells, including cell death or survival,
partially depending on how long it is exposed. Patients with cancer and under hypoxic …