Hepatocellular carcinoma (HCC) accounts for the majority of liver cancers. A hypoxic
microenvironment is a common feature of HCC, and is associated with malignant invasion …

Epithelial-mesenchymal transition (EMT), which is mainly recognized by upregulation of
mesenchymal markers and movement of cells, is a critical stage occurred during embryo …

Pancreatic cancer is a malignant disease without efficient treatment. Improved treatments
are urgently needed to enhance or replace chemotherapy. Here we used a small molecular …

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and lethal cancer, with poor
outcomes. Infection with the hepatitis B virus (HBV) may be associated as a worse prognosis …

Neuropathic pain perplexes a large population of patients with various diseases.
Inflammation plays a key role in the physiopathology of neuropathic pain. Anti-inflammatory …

Background We have previously described CLDN6 as a tumor suppressor gene in breast
cancer. Here, a new finding is that CLDN6 was upregulated under hypoxia, a commonly …

Background Tibetan cashmere goats are served as a valuable model for high altitude
adaptation and hypoxia complications related studies, while the cashmere produced by …

Background Hypoxia naturally happens in embryogenesis and thus serves as an important
environmental factor affecting embryo development. Hif-1α, an essential hypoxia response …

Hepatocellular carcinoma (HCC), with its high recurrence and metastasis rates, is a leading
cause of cancer-related mortality, and available treatments include surgical resection and …

Abstract Echinacea purpurea (L.) Moench (Ep) is widely used as a kind of dietary
supplements, and possesses various pharmacological activities, including …