PKM2 regulates hepatocellular carcinoma cell epithelial-mesenchymal transition and migration upon EGFR activation

FT Fan, CS Shen, L Tao, C Tian, ZG Liu… - Asian Pacific Journal …, 2014 - koreascience.kr
Pyruvate kinase isozyme type M2 (PKM2) was first found in hepatocellular carcinoma
(HCC), and its expression has been thought to correlate with prognosis. A large number of …

[HTML][HTML] TIPE2 inhibits hypoxia-induced Wnt/β-catenin pathway activation and EMT in glioma cells

Z Liu, H Liu, H Zhou, G Wang - Oncology research, 2016 - ncbi.nlm.nih.gov
Hypoxia-induced epithelial-to-mesenchymal transition (EMT) could facilitate tumor
progression. TIPE2, the tumor necrosis factor-α (TNF-α)-induced protein 8-like 2 (also known …

[HTML][HTML] A rice bran phytochemical, cyanidin 3-glucoside, inhibits the progression of PC3 prostate cancer cell

K Jongsomchai, V Leardkamolkarn… - Anatomy & cell …, 2020 - synapse.koreamed.org
Prostate cancer is one of the high incidences and the most invasive cancer that is also
highly resistant to chemotherapy. Currently, several natural products have been considering …

Nestin overexpression in hepatocellular carcinoma associates with epithelial-mesenchymal transition and chemoresistance

Y Zhang, S Zeng, J Ma, G Deng, Y Qu, C Guo… - Journal of Experimental …, 2016 - Springer
Background Nestin expression has been reported to be associated with the prognosis of
many solid tumors including human hepatocellular carcinoma (HCC). The present study …

Up-regulation of syncytin-1 contributes to TNF-α-enhanced fusion between OSCC and HUVECs partly via Wnt/β-catenin-dependent pathway

TL Yan, M Wang, Z Xu, CM Huang, XC Zhou… - Scientific reports, 2017 - nature.com
Accumulating evidence implies that cell fusion is one of the driving forces of cancer invasion
and metastasis. However, considerably less is still known about the triggering factors and …

[HTML][HTML] Hypoxia/Hif1α prevents premature neuronal differentiation of neural stem cells through the activation of Hes1

J Večeřa, J Procházková, V Šumberová, V Pánská… - Stem cell …, 2020 - Elsevier
Embryonic neural stem cells (NSCs), comprising neuroepithelial and radial glial cells, are
indispensable precursors of neurons and glia in the mammalian developing brain. Since the …

Daucosterol inhibits the proliferation, migration, and invasion of hepatocellular carcinoma cells via Wnt/β-catenin signaling

J Zeng, X Liu, X Li, Y Zheng, B Liu, Y Xiao - Molecules, 2017 - mdpi.com
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death
worldwide. The purpose of this study was to determine the effects of daucosterol on HCC by …

P53 and Vegf are promising biomarkers for Sorafenib efficacy in an experimental model of Nash-related Hcc

JP Nassar-Reis, PF Umeta, JT Stefano… - Journal of Molecular …, 2023 - Springer
The efficacy of systemic therapy for hepatocellular carcinoma (HCC) related to non-alcoholic
steatohepatitis (NASH) is poorly understood. In this study we evaluated the effects of …

Proteome analysis of hypoxic glioblastoma cells reveals sequential metabolic adaptation of one-carbon metabolic pathways

K Zhang, P Xu, JL Sowers, DF Machuca… - Molecular & Cellular …, 2017 - ASBMB
Rapidly proliferating tumors are exposed to a hypoxic microenvironment because of their
density, high metabolic consumption, and interruptions in blood flow because of immature …

Hypoxic microenvironment induces EMT and upgrades stem-like properties of gastric cancer cells

J Guo, B Wang, Z Fu, J Wei… - Technology in cancer …, 2016 - journals.sagepub.com
Hypoxia microenvironment, as a major feature of solid tumors, increases tumors progression
and metastasis. To research whether hypoxia influences the epithelial–mesenchymal …