Regulatory and pathogenic mechanisms in response to iron deficiency and excess in fungi

J Pijuan, DF Moreno, G Yahya, M Moisa… - Microbial …, 2023 - Wiley Online Library
Iron is an essential element for all eukaryote organisms because of its redox properties,
which are important for many biological processes such as DNA synthesis, mitochondrial …

The siderophore ferricrocin mediates iron acquisition in Aspergillus fumigatus

I Happacher, M Aguiar, M Alilou, B Abt… - Microbiology …, 2023 - Am Soc Microbiol
The opportunistic fungal pathogen Aspergillus fumigatus utilizes two high-affinity iron uptake
mechanisms, termed reductive iron assimilation (RIA) and siderophore-mediated iron …

Regulation of high-affinity iron acquisition, including acquisition mediated by the iron permease FtrA, is coordinated by AtrR, SrbA, and SreA in Aspergillus fumigatus

A Yap, R Volz, S Paul, WS Moye-Rowley, H Haas - MBio, 2023 - Am Soc Microbiol
Iron acquisition is crucial for virulence of the human pathogen Aspergillus fumigatus.
Previous studies indicated that this mold regulates iron uptake via both siderophores and …

[HTML][HTML] Fungal siderophore metabolism with a focus on Aspergillus fumigatus: Impact on biotic interactions and potential translational applications

I Happacher, M Aguiar, A Yap, C Decristoforo… - Essays in …, 2023 - ncbi.nlm.nih.gov
Iron is an essential trace element that is limiting in most habitats including hosts for fungal
pathogens. Siderophores are iron-chelators synthesized by most fungal species for high …

Distinct transcriptional responses to fludioxonil in Aspergillus fumigatus and its ΔtcsC and Δskn7 mutants reveal a crucial role for Skn7 in the cell wall …

S Schruefer, A Pschibul, SSW Wong, T Sae-Ong… - BMC genomics, 2023 - Springer
Background Aspergillus fumigatus is a major fungal pathogen that causes severe problems
due to its increasing resistance to many therapeutic agents. Fludioxonil is a compound that …

Fonsecaea pedrosoi produces ferricrocin and can utilize different host iron sources

KLP da Silva, D Moraes, B Lechner, H Lindner, H Haas… - Fungal Biology, 2023 - Elsevier
The survival of living organisms depends on iron, one of the most abundant metals in the
Earth's crust. Nevertheless, this micronutrient is poorly available in our aerobic atmosphere …

Iron Starvation Induces Ferricrocin Production and the Reductive Iron Acquisition System in the Chromoblastomycosis Agent Cladophialophora carrionii

AM Bailão, KLP Silva, D Moraes, B Lechner, H Lindner… - Journal of Fungi, 2023 - mdpi.com
Iron is a micronutrient required by almost all living organisms. Despite being essential, the
availability of this metal is low in aerobic environments. Additionally, mammalian hosts …

Biomimetic Analogues of the Desferrioxamine E Siderophore for PET Imaging of Invasive Aspergillosis: Targeting Properties and Species Specificity

A Mular, I Hubmann, M Petrik, K Bendova… - Journal of Medicinal …, 2024 - ACS Publications
The pathogenic fungus Aspergillus fumigatus utilizes a cyclic ferrioxamine E (FOXE)
siderophore to acquire iron from the host. Biomimetic FOXE analogues were labeled with …

The Transcription Factors AcuK and AcuM Influence Siderophore Biosynthesis of Aspergillus fumigatus

P Caballero, A Yap, MJ Bromley, H Haas - Journal of Fungi, 2024 - mdpi.com
The mold Aspergillus fumigatus employs two high-affinity uptake systems, reductive iron
assimilation (RIA) and siderophore-mediated iron acquisition (SIA), for the acquisition of the …

Characterization of Aspergillus fumigatus secretome during sublethal infection of Galleria mellonella larvae

A Curtis, P Dobes, J Marciniak… - Journal of Medical …, 2024 - microbiologyresearch.org
Introduction. The fungal pathogen Aspergillus fumigatus can induce prolonged colonization
of the lungs of susceptible patients, resulting in conditions such as allergic …