The autoimmune inflammatory myopathy disease spectrum, commonly known as myositis, is
a group of systemic diseases that mainly affect the muscles, skin and lungs. Biomarker …

The global statistics of bone disorders, skeletal defects, and fractures are frightening.
Several therapeutic strategies are being used to fix them; however, RNAi-based siRNA …

Hip fractures are associated with significant disability, high cost, and mortality. However, the
exact biological mechanisms underlying susceptibility to hip fractures remain incompletely …

Background Fibrinolysisis is essential for vascular blood flow maintenance and is triggered
by endothelial and platelet release of tissue plasminogen activator (t-PA). In certain critical …

Severe injuries, such as burns, provoke a systemic inflammatory response syndrome (SIRS)
that imposes pathology on all organs. Simultaneously, severe injury also elicits activation of …

We aimed to identify serum biomarkers that predict knee osteoarthritis (OA) before the
appearance of radiographic abnormalities in a cohort of 200 women. As few as six serum …

Short-chain fatty acids produced by the gut bacterial fermentation of non-digestible
carbohydrates, eg, fructo-oligosaccharide (FOS), contribute to the maintenance of skeletal …

The musculoskeletal system plays vital roles in the body, facilitating movement, protecting
vital structures, and regulating hematopoiesis and mineral metabolism. Injuries to this …

Pseudoxanthoma elasticum (PXE) is a heritable ectopic calcification disorder with
multiorgan clinical manifestations. The gene at default, ABCC6, encodes an efflux …

Objective Developing new therapies for knee osteoarthritis (KOA) requires improved
prediction of disease progression. This study evaluated the prognostic value of clinical …