The Slc26 proteins are a ubiquitous superfamily of anion transporters conserved from
bacteria to humans, among which four have been identified as human disease genes. Our …

The structure of the sodium/galactose transporter (vSGLT), a solute-sodium symporter (SSS)
from Vibrio parahaemolyticus, shares a common structural fold with LeuT of the …

Amino acid uptake in fungi is mediated by general and specialized members of the yeast
amino acid transporter (YAT) family, a branch of the amino acid polyamine organocation …

The K+–Cl− cotransporter 2 (KCC2) plays an important role in inhibitory neurotransmission,
and its impairment is associated with neurological and psychiatric disorders, including …

Prestin is a member of the SLC26 family of anion transporters that has evolved to serve as a
molecular motor in outer hair cells (OHCs) of the mammalian inner ear. The protein is …

Histidine is an important carbon and nitrogen source of γ‐proteobacteria and can affect
bacteria–host interactions. The mechanisms of histidine uptake are only partly understood …

Anabaena sp. strain PCC 7120 is a filamentous cyanobacterium that can use inorganic
compounds such as nitrate or ammonium as nitrogen sources. In the absence of combined …

Background Two of the largest fully sequenced prokaryotic genomes are those of the
actinobacterium, Streptomyces coelicolor (Sco), and the δ-proteobacterium, Myxococcus …

Most secondary-active transporters transport their substrates using an electrochemical ion
gradient. In contrast, the carnitine transporter (CaiT) is an ion-independent, l-carnitine/γ …

Membrane proteins play key roles in many biological processes, from acquisition of nutrients
to neurotransmission, and are targets for more than 50% of current therapeutic drugs …