Epithelial-to-Mesenchymal Transition (EMT) has been shown to be crucial in tumorigenesis
where the EMT program enhances metastasis, chemoresistance and tumor stemness. Due …

Epithelial‐to‐mesenchymal transition (EMT) is a fundamental process in development and
disease. Zinc‐finger enhancer binding (ZEB) transcription factors (ZEB1 and ZEB2) are …

Epithelial-mesenchymal transition (EMT) is critical for appropriate embryonic development,
and this process is re-engaged in adults during wound healing, tissue regeneration, organ …

Strong cell–cell interactions represent a major barrier against cancer cell mobility, and loss
of intercellular adhesion by E-cadherin is a fundamental change that occurs during the …

The limitations of current chemotherapeutic drugs are still a major issue in cancer treatment.
Thus, targeted multimodal therapeutic approaches need to be strategically developed to …

Epithelial (E)-cadherin is a homophilic adhesion molecule which is responsible for
maintenance of baso-lateral cell adhesion and polarity. E-cadherin can be lost from the cell …

Purpose: We have reported loss of SMAD4 promotes expression of CCL15 from colorectal
cancer to recruit CCR1+ myeloid cells through the CCL15-CCR1 axis, which contributes to …

Background Altered levels of circulating adhesion molecules found in several carcinomas,
including lung cancer, reflect local loss of diffusion barriers and tumor volume and can be …

ABSTRACT Background This phase Ib study evaluated volociximab, an anti-α5β1 integrin
antibody, in combination with carboplatin (Eli Lilly and Co., Indianapolis, IN) and paclitaxel …

Over the past decade, a multitude of targeted agents have been explored in the treatment of
advanced non–small cell lung cancer (NSCLC). Thus far, two broad classes of agents have …