The role of HO-1 and its crosstalk with oxidative stress in cancer cell survival
SK Chiang, SE Chen, LC Chang - Cells, 2021 - mdpi.com
Heme oxygenases (HOs) act on heme degradation to produce carbon monoxide (CO), free
iron, ferritin, and biliverdin. Upregulation of cellular HO-1 levels is signature of oxidative …
iron, ferritin, and biliverdin. Upregulation of cellular HO-1 levels is signature of oxidative …
Antioxidant effects of resveratrol in the cardiovascular system
The antioxidant effects of resveratrol (3, 5, 4'‐trihydroxy‐trans‐stilbene) contribute
substantially to the health benefits of this compound. Resveratrol has been shown to be a …
substantially to the health benefits of this compound. Resveratrol has been shown to be a …
Heme oxygenases in cardiovascular health and disease
Heme oxygenases are composed of two isozymes, Hmox1 and Hmox2, that catalyze the
degradation of heme to carbon monoxide (CO), ferrous iron, and biliverdin, the latter of …
degradation of heme to carbon monoxide (CO), ferrous iron, and biliverdin, the latter of …
Hmox1 (Heme Oxygenase-1) protects against ischemia-mediated injury via stabilization of HIF-1α (Hypoxia-Inducible Factor-1α)
Objective: Hmox1 (heme oxygenase-1) is a stress-induced enzyme that catalyzes the
degradation of heme to carbon monoxide, iron, and biliverdin. Induction of Hmox1 and its …
degradation of heme to carbon monoxide, iron, and biliverdin. Induction of Hmox1 and its …
Methyltransferase like 7B is a potential therapeutic target for reversing EGFR-TKIs resistance in lung adenocarcinoma
H Song, D Liu, L Wang, K Liu, C Chen, L Wang, Y Ren… - Molecular cancer, 2022 - Springer
Background Identification of potential novel targets for reversing resistance to Epidermal
Growth Factor Receptor (EGFR)-tyrosine kinase inhibitors (EGFR-TKIs) holds great promise …
Growth Factor Receptor (EGFR)-tyrosine kinase inhibitors (EGFR-TKIs) holds great promise …
HO-1/CO system in tumor growth, angiogenesis and metabolism—Targeting HO-1 as an anti-tumor therapy
A Loboda, A Jozkowicz, J Dulak - Vascular pharmacology, 2015 - Elsevier
Abstract Heme oxygenase-1 (HO-1, hmox-1) catalyzes the rate-limiting step in the heme
degradation processes. Out of three by-products of HO-1 activity, biliverdin, iron ions and …
degradation processes. Out of three by-products of HO-1 activity, biliverdin, iron ions and …
Kidney cadmium toxicity, diabetes and high blood pressure: The Perfect Storm
S Satarug, DA Vesey, GC Gobe - The Tohoku journal of experimental …, 2017 - jstage.jst.go.jp
Cadmium (Cd) is an environmental toxicant of widespread exposure and pervasive toxicity.
Absorption, systemic transport and uptake of Cd are mediated by metal transporters that the …
Absorption, systemic transport and uptake of Cd are mediated by metal transporters that the …
Heme oxygenase-1 deficiency and oxidative stress: a review of 9 independent human cases and animal models
A Yachie - International Journal of Molecular Sciences, 2021 - mdpi.com
Since Yachie et al. reported the first description of human heme oxygenase (HO)-1
deficiency more than 20 years ago, few additional human cases have been reported in the …
deficiency more than 20 years ago, few additional human cases have been reported in the …
[HTML][HTML] Functional genomics identifies metabolic vulnerabilities in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDA) is a deadly cancer characterized by complex
metabolic adaptations that promote survival in a severely hypoxic and nutrient-limited tumor …
metabolic adaptations that promote survival in a severely hypoxic and nutrient-limited tumor …
Roles of heme oxygenase-1 in neuroinflammation and brain disorders
YH Wu, HL Hsieh - Antioxidants, 2022 - mdpi.com
The heme oxygenase (HO) system is believed to be a crucial mechanism for the nervous
system under stress conditions. HO degrades heme to carbon monoxide, iron, and …
system under stress conditions. HO degrades heme to carbon monoxide, iron, and …