Excessive abnormal angiogenesis plays a pivotal role in tumor progression and is a
hallmark of solid tumors. This process is driven by an imbalance between pro-and anti …

Abstract Chalcone or (E)-1, 3-diphenyl-2-propene-1-one scaffold remained a fascination
among researchers in the 21st century due to its simple chemistry, ease of synthesis and a …

Hepatocellular carcinoma (HCC) is swiftly increasing in prevalence globally with a high
mortality rate. The progression of HCC in patients is induced with advanced fibrosis, mainly …

The tumor microenvironment (TME) is essential for immune escape by tumor cells. It plays
essential roles in tumor development and metastasis. The clinical outcomes of tumors are …

Pancreatic cancer is one of the most lethal malignancies worldwide. Although the standard
of care in pancreatic cancer has improved, prognoses for patients remain poor with a 5-year …

With the advent of next generation sequencing methods and progress in transcriptome
analysis, it became obvious that the human genome contains much more than just protein …

Nanoparticles have emerged as promising drug delivery systems for the treatment of several
diseases. Novel cancer therapies have exploited these particles as alternative adjuvant …

The hallmarks of cancer comprise six biological capabilities acquired during the multistep
development of human tumors. The hallmarks constitute an organizing principle for …

Introduction Fibroblast activation protein (FAP) is highly overexpressed in stromal tissue of
various cancers. While FAP has been recognized as a potential diagnostic or therapeutic …

Angiogenesis is the process of formation of new blood vessels from existing ones. Vessels
serve the purpose of providing oxygen, nutrients and removal of waste from the cells. The …