In this issue of Structure, Holmes et al.(2005) describe elements of an innate defense
mechanism that provides mammals a means to restrict bacterial growth. The host protein …

Objective Longitudinal structural MRI studies have shown that patients with schizophrenia
have progressive brain tissue loss after onset. Recurrent relapses are believed to play a role …

Background Consensus panel recommendations regarding choice of an antipsychotic agent
for schizophrenia differ markedly, but most consider second-generation antipsychotics …

Cognitive impairment is a core feature of schizophrenia and a major impediment to social
and vocational rehabilitation. A number of studies have claimed cognitive benefits from …

OBJECTIVE: Based on lower rates of acute extrapyramidal side effects associated with
second-generation antipsychotics, compared to first-generation antipsychotics, and based …

The National Institute of Mental Health convened a meeting in October 2005 to review the
literature on obesity, nutrition, and physical activity among those with mental disorders. The …

Importance Treatment nonadherence and relapse are common problems in patients with
schizophrenia. The long-acting 3-month formulation of paliperidone palmitate, owing to its …

Antipsychotic drugs can be of great benefit in a range of psychiatric disorders, including
schizophrenia and bipolar disorder, but all are associated with a wide range of potential …

Open Forum a period of sobriety, the use of an operational definition of recovery requires
them to remain abstinent for a defined period and to function with a “clean and sober,” …

Abstract BACKGROUND: The Royal Australian and New Zealand College of Psychiatrists is
co-ordinating the development of clinical practice guidelines (CPGs) in psychiatry, funded …