Oxidative stress and chronic inflammation in osteoarthritis: can NRF2 counteract these partners in crime?
AS Marchev, PA Dimitrova, AJ Burns… - Annals of the New …, 2017 - Wiley Online Library
Osteoarthritis (OA) is an age‐related joint degenerative disease associated with pain, joint
deformity, and disability. The disease starts with cartilage damage but then progressively …
deformity, and disability. The disease starts with cartilage damage but then progressively …
[HTML][HTML] Skeletal muscle wasting and its relationship with osteoarthritis: a mini-review of mechanisms and current interventions
E Shorter, AJ Sannicandro, B Poulet… - Current Rheumatology …, 2019 - Springer
Abstract Purpose of Review Osteoarthritis (OA) is a subset of joint disorders resulting in
degeneration of synovial joints. This leads to pain, disability and loss of independence …
degeneration of synovial joints. This leads to pain, disability and loss of independence …
[HTML][HTML] Dual functions of microRNA-17 in maintaining cartilage homeostasis and protection against osteoarthritis
Y Zhang, S Li, P Jin, T Shang, R Sun, L Lu… - Nature …, 2022 - nature.com
Damaged hyaline cartilage has no capacity for self-healing, making osteoarthritis
(OA)“difficult-to-treat”. Cartilage destruction is central to OA patho-etiology and is mediated …
(OA)“difficult-to-treat”. Cartilage destruction is central to OA patho-etiology and is mediated …
Inhibition of PI3K/AKT/mTOR signaling pathway promotes autophagy of articular chondrocytes and attenuates inflammatory response in rats with osteoarthritis
JF Xue, ZM Shi, J Zou, XL Li - Biomedicine & Pharmacotherapy, 2017 - Elsevier
Objective This study aims to explore the relationship between PI3K/AKT/mTOR signaling
pathway and autophagy of articular chondrocytes in rats with osteoarthritis (OA). Methods …
pathway and autophagy of articular chondrocytes in rats with osteoarthritis (OA). Methods …
[HTML][HTML] Exosomes derived from platelet-rich plasma present a novel potential in alleviating knee osteoarthritis by promoting proliferation and inhibiting apoptosis of …
X Liu, L Wang, C Ma, G Wang, Y Zhang… - Journal of orthopaedic …, 2019 - Springer
Background Platelet-rich plasma (PRP) provides a nonsurgical approach for treating
osteoarthritis (OA). Exosomes that play vital roles in intercellular communication have been …
osteoarthritis (OA). Exosomes that play vital roles in intercellular communication have been …
[HTML][HTML] Copper-incorporated bioactive glass-ceramics inducing anti-inflammatory phenotype and regeneration of cartilage/bone interface
R Lin, C Deng, X Li, Y Liu, M Zhang, C Qin, Q Yao… - Theranostics, 2019 - ncbi.nlm.nih.gov
Osteoarthritis not only results in cartilage lesion, but also is accompanied with subchondral
bone damage caused by the inflammatory response. It is of great significance to treat …
bone damage caused by the inflammatory response. It is of great significance to treat …
Exosomal KLF3-AS1 from hMSCs promoted cartilage repair and chondrocyte proliferation in osteoarthritis
Y Liu, R Zou, Z Wang, C Wen, F Zhang… - Biochemical …, 2018 - portlandpress.com
The present study was designed to explore whether exosomal lncRNA-KLF3-AS1 derived
from human mesenchymal stem cells (hMSCs) can serve as a positive treatment for …
from human mesenchymal stem cells (hMSCs) can serve as a positive treatment for …
Exosomes and stem cells in degenerative disease diagnosis and therapy
YH Chang, KC Wu, HJ Harn, SZ Lin… - Cell …, 2018 - journals.sagepub.com
Stroke can cause death and disability, resulting in a huge burden on society. Parkinson's
disease (PD) is a chronic neurodegenerative disorder characterized by motor dysfunction …
disease (PD) is a chronic neurodegenerative disorder characterized by motor dysfunction …
Tannic acid/Sr2+-coated silk/graphene oxide-based meniscus scaffold with anti-inflammatory and anti-ROS functions for cartilage protection and delaying …
Tissue engineering method provides a promising solution for meniscus repair and
regeneration. However, the inflammatory environment that persists after meniscus injury in …
regeneration. However, the inflammatory environment that persists after meniscus injury in …
[HTML][HTML] Mitochondria: potential targets for osteoarthritis
X Mao, P Fu, L Wang, C Xiang - Frontiers in medicine, 2020 - frontiersin.org
Osteoarthritis (OA) is a common and disabling joint disorder that is mainly characterized by
cartilage degeneration and narrow joint spaces. The role of mitochondrial dysfunction in …
cartilage degeneration and narrow joint spaces. The role of mitochondrial dysfunction in …