In a healthy body, reactive oxygen species (ROS) and antioxidants remain balanced. When
the balance is broken toward an overabundance of ROS, oxidative stress appears and may …

Abstract Sirtuin 3 (SIRT3) is one of the most prominent deacetylases that can regulate
acetylation levels in mitochondria, which are essential for eukaryotic life and inextricably …

Melatonin is an immune modulator that displays both pro‐and anti‐inflammatory properties.
Proinflammatory actions, which are well documented by many studies in isolated cells or …

Ovarian aging refers to the process by which ovarian function declines until eventual failure.
The pathogenesis of ovarian aging is complex and diverse; oxidative stress (OS) is …

Reproductive capacity in women starts to decline beyond their mid-30s and pregnancies in
older women result in higher rates of miscarriage with aneuploidy. Age-related decline in …

BACKGROUND Advanced maternal age is associated with decreased oocyte quantity and
quality as well as uterine and placental dysfunctions. These changes lead to infertility …

Sirtuins are a family of highly evolutionarily conserved nicotinamide adenine nucleotide‐
dependent histone deacetylases. Sirtuin‐3 (SIRT 3) is a member of the sirtuin family that is …

Melatonin is an ancient molecule that originated in bacteria. When these prokaryotes were
phagocytized by early eukaryotes, they eventually developed into mitochondria and …

Reactive oxygen species (ROS) are mainly produced in mitochondria and are involved in
various physiological activities of the ovary through signaling and are critical for regulating …

Melatonin is probably produced in all cells but is only secreted by the pineal gland. The
pineal secretion of melatonin is determined by the light–dark cycle, and it is only released at …