Ceramide is a lipid messenger at the heart of sphingolipid metabolism. In concert with its
metabolizing enzymes, particularly sphingomyelinases, it has key roles in regulating the …

Sphingolipids not only exert structural roles in cellular membranes, but also act as signaling
molecules in various physiological and pathological processes. A myriad of studies have …

HIV-1 assembly occurs at the inner leaflet of the plasma membrane (PM) in highly ordered
membrane microdomains. The size and stability of membrane microdomains is regulated by …

Although the human immunodeficiency virus type 1 lipid envelope has been reported to be
enriched with host cell sphingomyelin and cholesterol, the molecular mechanism of the …

Metabolic pathways are complex and intertwined. Deficiencies in one or more enzymes in a
given pathway are directly linked with genetic diseases, most of them having devastating …

Classical swine fever virus (CSFV) is a highly pathogenic RNA virus belonging to the
Flaviviridae family that can cause deadly classical swine fever (CSF) in pigs. However, the …

The present study demonstrates that, in addition to interacting with galactosylceramide
(GalCer), HIV-1, HIV-2, and SIV envelope glycoproteins are able to interact with …

Membrane trafficking is essential to maintain the spatiotemporal control of protein and lipid
distribution within membrane systems of eukaryotic cells. To achieve their functional …

Serine incorporator 5 (SER5) is a protein that upon incorporation into virions inhibits HIV-1
infectivity by interfering with the ability of the Env glycoprotein to promote viral fusion. The …

Background Alcoholic liver disease (ALD) is one of the most prevalent chronic liver disease
worldwide. Alcohol-induced alterations in hepatic lipids play an important role in ALD …