Antibodies are a vital part of the armamentarium of the adaptive immune system for the fine-
tuning of the recognition and response to foreign threats. However, in health there are some …

Natural IgM are highly represented in the circulation at birth, and these often autoreactive
antibodies have been postulated to have innate-like properties and play crucial roles in …

B-1a cells are distinguished from conventional B cells (B2) by their developmental origin,
their surface marker expression and their functions. They were originally identified as a B …

CD5+ B cells have attracted considerable interest because of their association with self-
reactivity, autoimmunity, and leukemia. In mice, CD5+ B cells are readily generated from …

B1 B cells are the major source of natural antibody that is essential for innate immunity. The
B1 repertoire is skewed toward production of phosphatidylcholine (PtC)‐binding VH11 and …

Innate-like B-1a cells provide a first line of defense against pathogens, yet little is known
about their transcriptional control. Here we identified an essential role for the transcription …

Inhibition of antigen-dependent B-cell receptor (BCR) signaling is considered a promising
therapeutic approach in chronic lymphocytic leukemia (CLL), but experimental in vivo …

Intraepithelial lymphocytes constitute a group of T cells that express mainly monospecific or
oligoclonal T cell receptors (TCRs). Like adaptive TCRαβ+ T cells, intraepithelial …

Chronic lymphocytic leukemia (CLL) is uniquely characterized by the existence of subsets of
cases with quasi-identical,'stereotyped'B-cell receptors (BCRs). Herein we investigate this …

B-1 (CD5+) B cells constitute a phenotypic and functionally distinct population of B cells in
mouse that show enriched expression of autoreactive B-cell antigen receptors and that …