Ubiquitination is a key regulatory mechanism vital for maintenance of cellular homeostasis.
Protein degradation is induced by E3 ligases via attachment of ubiquitin chains to …

Targeted protein degradation (TPD) has emerged as a new modality in drug discovery. In
this approach, small molecules are used to drive degradation of the target protein of interest …

Protein ubiquitylation plays important roles in many biological activities. Protein
ubiquitylation is a unique process that is mainly controlled by ubiquitin ligases. The ubiquitin …

Genomic instability, microenvironmental aberrations, and somatic mutations contribute to the
phenotype of myelodysplastic syndrome and the risk for transformation to AML. Genes …

Chemically induced proximity-based targeted protein degradation (TPD) has become a
prominent paradigm in drug discovery. With the clinical benefit demonstrated by certain …

RNA splicing is a key component of gene expression and proteomic diversity in humans.
The spliceosome assembles on and processes individual nascent pre-mRNA transcripts into …

Introduction Bromodomain-containing protein 4 (BRD4), an important epigenetic reader, is
closely associated with the pathogenesis and development of many diseases, including …

Unlocking novel E3 ligases for use in heterobifunctional PROTAC degraders is of high
importance to the pharmaceutical industry. Over-reliance on the current suite of ligands used …

Targeted protein degradation (TPD) is a rapidly expanding field, with various PROTACs
(proteolysis-targeting chimeras) in clinical trials and molecular glues such as …

Targeted protein degradation is a drug modality represented by compounds that recruit a
target to an E3 ubiquitin ligase to promote target ubiquitination and proteasomal …