Structural biology offers a versatile arsenal of techniques and methods to investigate the
structure and conformational dynamics of proteins and their assemblies. The growing field of …

Whereas oncogenes can potentially be inhibited with small molecules, the loss of tumour
suppressors is more common and is problematic because the tumour-suppressor proteins …

Cells use many post-translational modifications (PTMs) to tailor proteins and transduce
cellular signals. Recent years have witnessed the rapid growth of small molecule and …

Targeted protein degradation is a drug modality represented by compounds that recruit a
target to an E3 ubiquitin ligase to promote target ubiquitination and proteasomal …

Targeted protein degradation (TPD) has emerged as a new modality in drug discovery. In
this approach, small molecules are used to drive degradation of the target protein of interest …

Protein ubiquitylation plays important roles in many biological activities. Protein
ubiquitylation is a unique process that is mainly controlled by ubiquitin ligases. The ubiquitin …

Molecular glue (MG) degraders are monovalent small molecule compounds that co-opt E3
ubiquitin ligases to target neo-substrates for proteasomal degradation. Here, we provide a …

Ubiquitination is a key regulatory mechanism vital for maintenance of cellular homeostasis.
Protein degradation is induced by E3 ligases via attachment of ubiquitin chains to …

Chemically induced proximity-based targeted protein degradation (TPD) has become a
prominent paradigm in drug discovery. With the clinical benefit demonstrated by certain …

Targeted protein degradation is a pharmacological modality that is based on the induced
proximity of an E3 ubiquitin ligase and a target protein to promote target ubiquitination and …