Lipid–polymer hybrid nanoparticles loaded with N-acetylcysteine for the modulation of neuroinflammatory biomarkers in human iPSC-derived PSEN2 (N141I) …

A Vargas-Barona, J Bernáldez-Sarabia… - Journal of Materials …, 2024 - pubs.rsc.org
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by
cognitive impairment associated with the accumulation of beta-amyloid protein (Aβ). Aβ …

[HTML][HTML] To see or not to see: In vivo nanocarrier detection methods in the brain and their challenges

AC Wehn, E Krestel, BN Harapan… - Journal of Controlled …, 2024 - Elsevier
Nanoparticles have a great potential to significantly improve the delivery of therapeutics to
the brain and may also be equipped with properties to investigate brain function. The brain …

Unveiling the neuroprotective properties of isoflavones: current evidence, molecular mechanisms and future perspectives

G Gong, K Ganesan, Y Wan, Y Liu… - Critical Reviews in …, 2024 - Taylor & Francis
Neurodegenerative diseases encompass a wide range of debilitating and incurable brain
disorders characterized by the progressive deterioration of the nervous system's structure …

Baseline and time‐updated factors in preclinical development of anionic dendrimers as successful anti‐HIV‐1 vaginal microbicides

I Rodríguez‐Izquierdo… - Wiley …, 2022 - Wiley Online Library
Although a wide variety of topical microbicides provide promising in vitro and in vivo efficacy,
most of them failed to prevent sexual transmission of human immunodeficiency virus type 1 …

[HTML][HTML] Roadmap on nanomedicine for the central nervous system

G Ciofani, M Campisi, C Mattu, RD Kamm… - Journal of Physics …, 2023 - iopscience.iop.org
In recent years, a great deal of effort has been undertaken with regards to treatment of
pathologies at the level of the central nervous system (CNS). Here, the presence of the …

Review of Pharmacotherapeutic Targets in Alzheimer's Disease and Its Management Using Traditional Medicinal Plants

PN Tripathi, A Lodhi, SN Rai, NK Nandi… - Degenerative …, 2024 - Taylor & Francis
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by
cognitive decline, memory loss, and impaired daily functioning. While there is currently no …

Lipid nanoparticle mediated small interfering RNA delivery as a potential therapy for Alzheimer's disease

T Ahmed - European Journal of Neuroscience, 2024 - Wiley Online Library
Alzheimer's disease (AD) is a neurodegenerative condition that exhibits a gradual decline in
cognitive function and is prevalent among a significant number of individuals globally. The …

Nanotherapeutics of phytoantioxidants for CNS disorders

A Paul, N Guha, MK Zaman - Phytoantioxidants and …, 2022 - Wiley Online Library
Central nervous system (CNS) disorders have a major impact on public health and, as such,
have gained the interest of researchers to search for better strategies. Recently, the field of …

Nanomedicine-driven therapeutic interventions of autophagy and stem cells in the management of Alzheimer's disease

FS Alhodieb, MA Rahman, MA Barkat, AA Alanezi… - …, 2023 - Taylor & Francis
Drug-loaded, brain-targeted nanocarriers could be a promising tool in overcoming the
challenges associated with Alzheimer's disease therapy. These nanocargoes are …

[HTML][HTML] Gallium nanoparticles as novel inhibitors of Aβ40 aggregation

KM Torres, AS Delgado, ER Serrano… - Materials …, 2021 - pubs.rsc.org
Alzheimer's disease (AD) has been consistently related to the formation of senile amyloid
plaques mainly composed of amyloid β (Aβ) peptides. The toxicity of Aβ aggregates has …