Inflammatory bowel disease: an overview of immune mechanisms and biological treatments

BRR de Mattos, MPG Garcia… - Mediators of …, 2015 - Wiley Online Library
Inflammatory bowel diseases (IBD) are characterized by chronic inflammation of the
intestinal tract associated with an imbalance of the intestinal microbiota. Crohn's disease …

Role of adipose tissue in inflammatory bowel disease

E Karaskova, M Velganova-Veghova, M Geryk… - International journal of …, 2021 - mdpi.com
Inflammatory bowel diseases (IBDs), chronic inflammatory disorders affecting the
gastrointestinal tract, include Crohn's disease and ulcerative colitis. There are increasing …

The safety of autologous and metabolically fit bone marrow mesenchymal stromal cells in medically refractory Crohn's disease–a phase 1 trial with three doses

T Dhere, I Copland, M Garcia… - Alimentary …, 2016 - Wiley Online Library
Background Mesenchymal stromal cells ability to reset immune functionalities may be useful
in Crohn's disease. Aim To perform a first‐in‐human phase 1 safety clinical trial of …

Results from the first‐in‐human study with ozanimod, a novel, selective sphingosine‐1‐phosphate receptor modulator

JQ Tran, JP Hartung, RJ Peach… - The Journal of …, 2017 - Wiley Online Library
Abstract The sphingosine‐1‐phosphate 1 receptor (S1P1R) is expressed by lymphocytes,
dendritic cells, and vascular endothelial cells and plays a role in the regulation of chronic …

Morphologic and immunohistochemical characterization of granulomas in the nucleotide oligomerization domain 2–related disorders Blau syndrome and Crohn …

CEI Janssen, CD Rose, G De Hertogh… - Journal of Allergy and …, 2012 - Elsevier
BACKGROUND: Blau syndrome (BS) and Crohn disease (CD) are both characterized by
granulomatous inflammation and related to nucleotide oligomerization domain 2 (NOD2) …

Hepatotoxicity caused by methotrexate therapy in children with inflammatory bowel disease: a systematic review and meta-analysis

PL Valentino, PC Church, PS Shah… - Inflammatory bowel …, 2014 - academic.oup.com
Background Methotrexate (MTX) is an immunomodulator used in pediatric inflammatory
bowel disease (IBD) maintenance regimens. However, MTX use is associated with liver …

MR enterography in pediatric inflammatory bowel disease: retrospective assessment of patient tolerance, image quality, and initial performance estimates

I Absah, DH Bruining, JM Matsumoto… - American Journal of …, 2012 - Am Roentgen Ray Soc
OBJECTIVE. The purpose of this article was to evaluate image quality, oral contrast
administration and bowel distention, side effects, and performance estimates of MR …

Hepcidin in newly diagnosed inflammatory bowel disease in children

E Karaskova, J Volejnikova, D Holub… - … of Paediatrics and …, 2018 - Wiley Online Library
Aim Hepcidin is a central regulator of iron homeostasis. Its production is also influenced by
systemic inflammation. The aims of this study were to compare hepcidin levels in paediatric …

[HTML][HTML] Circulating levels of WISP-1 (Wnt1-inducible signaling pathway protein 1) and other selected adipokines in children with inflammatory bowel disease

E Karaskova, V Kubickova… - Physiological …, 2022 - ncbi.nlm.nih.gov
Wnt1 inducible protein-1 signaling pathway (WISP-1) is a relatively new adipokine involved
in many cellular processes, including epithelial mucosa healing. The aim of the study was to …

Is it an eating disorder, gastrointestinal disorder, or both?

EM Bern, RF O'Brien - Current Opinion in Pediatrics, 2013 - journals.lww.com
Is it an eating disorder, gastrointestinal disorder, or both... : Current Opinion in Pediatrics Is it
an eating disorder, gastrointestinal disorder, or both? : Current Opinion in Pediatrics Log in or …