Histamine is a developmentally highly conserved autacoid found in most vertebrate tissues.
Its physiological functions are mediated by four 7-transmembrane G protein–coupled …

The neurotransmitter histamine receives less attention compared with other biogenic
amines, because of its moderate action in the central nervous system (CNS). However …

A single receptor can activate multiple signaling pathways that have distinct or even
opposite effects on cell function. Biased agonists stabilize receptor conformations …

Histamine has long been recognised as a classical inducer of pruritus. However, the specific
mechanism of histamine-induced itch has still not been fully understood. The H1 and H4 …

Membranous adenylyl cyclases (mACs) constitute a family of nine isoforms with different
expression patterns. Studies with mAC gene knockout mice provide evidence for the notion …

Histamine, a biogenic amine, is considered as a principle mediator of multiple physiological
effects through binding to its H 1, H 2, H 3, and H 4 receptors (H1–H4Rs). Currently, the HRs …

Combination of AChE inhibiting and histamine H3 receptor antagonizing properties in a
single molecule might show synergistic effects to improve cognitive deficits in Alzheimer's …

The histamine H4 receptor (H4R) is expressed in several cell types of the immune system
and is assumed to play an important pro-inflammatory role in various diseases, including …

Histamine is a biogenic amine that exerts its biological effects as a neurotransmitter and
local mediator via four histamine receptor (HR) subtypes (H x Rs)–H 1 R, H 2 R, H 3 R, and …

Eosinophils play a crucial role in the pathogenesis of allergic diseases. Histamine activates
eosinophils via the H4-receptor (H4R). However, pharmacological analysis of the H4R in …