Nitric oxide (NO) is undoubtedly quite an important intercellular messenger in cerebral and
peripheral hemodynamics. This molecule, formed by constitutive isomers of NO synthase …

The cerebrovascular endothelium exerts a profound influence on cerebral vessels and
cerebral blood flow. This review summarizes current knowledge of various dilator and …

Small conductance calcium-activated potassium (SK or K Ca 2) channels link intracellular
calcium transients to membrane potential changes. SK channel subtypes present different …

Objective—Angiotensin II (AngII) disrupts the regulation of the cerebral circulation through
superoxide, a reactive oxygen species (ROS) generated by a nox2-containing NADPH …

Nitric oxide (radical dot NO)-dependent pathways and cerebrovascular dysfunction have
been shown to contribute to the cognitive decline and neurodegeneration observed in …

There is now strong evidence that an endothelial mechanism, other than nitric oxide or
prostacyclin, exists for dilating arteries and arterioles. This third pathway has been named …

Control of cerebral vasculature differs from that of systemic vessels outside the blood-brain
barrier. The hypothesis that the endothelium modulates vasomotion via direct …

Large epidemiological studies have shown that traffic noise promotes the development of
cardiometabolic diseases. It remains to be established how long these adverse effects of …

Angiotensin II (Ang II) promotes vascular disease through several mechanisms including by
producing oxidative stress and endothelial dysfunction. Although multiple potential sources …

Background and Purpose—Obesity is an increasing epidemic worldwide; however, little is
known about effects of obesity produced by high-fat diet (HFD) on the cerebral circulation …