Neuroinflammation has positive and negative effects. This review focuses on the roles of
macrophage in the PNS. Transection of PNS axons leads to degeneration and clearance of …

Spinal cord injury (SCI) is a devastating neurological disorder that affects thousands of
individuals each year. Over the past decades an enormous progress has been made in our …

Axonal regeneration and formation of tripartite (axo-glial) junctions at damaged sites is a
prerequisite for early repair of injured spinal cord. Transplantation of stem cells at such sites …

Minocycline is a second‐generation, semi‐synthetic tetracycline that has been in therapeutic
use for over 30 years because of its antibiotic properties against both gram‐positive and …

Stroke is the second most common cause of death worldwide and a major cause of acquired
disability in adults. Despite tremendous progress in understanding the pathophysiology of …

The p38 MAPK protein kinases affect a variety of intracellular responses, with well-
recognized roles in inflammation, cell-cycle regulation, cell death, development …

Traumatic spinal cord injury (SCI) results not only in motor impairment but also in chronic
central pain, which can be refractory to conventional treatment approaches. It has been …

Minocycline is a semi-synthetic, second-generation tetracycline analog which is effectively
crossing the blood–brain barrier, effective against gram-positive and-negative infections. In …

Objective: Minocycline rescued synaptic abnormalities and improved behavior in the fragile
X mouse model. Previous open-label human studies demonstrated benefits in individuals …

The lack of robust treatment options available for neurodegenerative diseases, stroke, and
central nervous system (CNS) trauma, all of which often involve both inflammation and …