Genomic diagnosis of rare pediatric disease in the United Kingdom and Ireland

CF Wright, P Campbell, RY Eberhardt… - … England Journal of …, 2023 - Mass Medical Soc
Background Pediatric disorders include a range of highly penetrant, genetically
heterogeneous conditions amenable to genomewide diagnostic approaches. Finding a …

Cerebellar and striatal implications in autism spectrum disorders: from clinical observations to animal models

M Thabault, V Turpin, A Maisterrena, M Jaber… - International Journal of …, 2022 - mdpi.com
Autism spectrum disorders (ASD) are complex conditions that stem from a combination of
genetic, epigenetic and environmental influences during early pre-and postnatal childhood …

Neurodevelopmental outcomes in children exposed to newer antiseizure medications: A systematic review

R Knight, A Wittkowski, RL Bromley - Epilepsia, 2021 - Wiley Online Library
As prenatal exposure to certain older antiseizure medications (ASMs) has been linked with
poorer neurodevelopmental outcomes in children, the use of newer ASMs throughout …

Association of prenatal exposure to antiseizure medication with risk of autism and intellectual disability

MH Bjørk, H Zoega, MK Leinonen, JM Cohen… - JAMA …, 2022 - jamanetwork.com
Importance Women with epilepsy frequently need antiseizure medication (ASM) to prevent
seizures in pregnancy. Risk of neurodevelopmental disorders after prenatal exposure to …

Risk of Autism after Prenatal Topiramate, Valproate, or Lamotrigine Exposure

S Hernández-Díaz, L Straub, BT Bateman… - … England Journal of …, 2024 - Mass Medical Soc
Background Maternal use of valproate during pregnancy has been associated with an
increased risk of neurodevelopmental disorders in children. Although most studies of other …

Prenatal exposure to antiseizure medication and incidence of childhood-and adolescence-onset psychiatric disorders

JW Dreier, MH Bjørk, S Alvestad, M Gissler… - JAMA …, 2023 - jamanetwork.com
Importance Prenatal antiseizure medication (ASM) exposure has been associated with
adverse early neurodevelopment, but associations with a wider range of psychiatric end …

Status epilepticus in pregnancy: a literature review and a protocol proposal

R Roberti, M Rocca, LF Iannone… - Expert Review of …, 2022 - Taylor & Francis
Introduction Status epilepticus (SE) in pregnancy represents a life-threatening medical
emergency for both mother and fetus. Pregnancy-related pharmacokinetic modifications and …

Neurodevelopmental and functional outcomes following in utero exposure to antiseizure medication: a systematic review

E Honybun, E Cockle, CB Malpas, TJ O'Brien… - Neurology, 2024 - AAN Enterprises
Background and Objectives To undertake a systematic review of the available literature to
examine the relationship between prenatal antiseizure medication (ASM) exposure and …

Serotonin-related rodent models of early-life exposure relevant for neurodevelopmental vulnerability to psychiatric disorders

TS Adjimann, CV Argañaraz, M Soiza-Reilly - Translational psychiatry, 2021 - nature.com
Mental disorders including depression and anxiety are continuously rising their prevalence
across the globe. Early-life experience of individuals emerges as a main risk factor …

Medically Assisted Reproduction and Risk of Cancer Among Offspring

P Rios, P Herlemont, P Fauque, B Lacour… - JAMA Network …, 2024 - jamanetwork.com
Importance Cancer is a leading cause of death among children worldwide. Treatments used
for medically assisted reproduction (MAR) are suspected risk factors because of their …