New blood vessel formation (angiogenesis) is fundamental to tumor growth, invasion, and
metastatic dissemination. The vascular endothelial growth factor (VEGF) signaling pathway …

Vascular endothelial growth factor (VEGF) is a key regulator of angiogenesis which drives
endothelial cell survival, proliferation, and migration while increasing vascular permeability …

Epithelial ovarian cancer has the highest mortality rate of all gynaecological malignancies.
Most women present with advanced disease and develop a recurrence after radical surgery …

Background Bevacizumab is an exogenous inhibitor which inhibits the biological activity of
human VEGF. Several studies have investigated the effectiveness of bevacizumab therapy …

Background A previous dose-escalation trial of the vascular disrupting agent combretastatin
A4 phosphate (CA4P) given before carboplatin, paclitaxel, or both showed responses in 7 of …

OBJECTIVE: To review the rationale for targeting the vascular endothelial growth factor
(VEGF), platelet-derived growth factor (PDGF), and fibroblast growth factor (FGF) pathways …

MicroRNAs (miRNAs) are small noncoding RNAs that have important roles in gene
regulation. We have previously reported that activin receptor-like kinase 7 (ALK7) and its …

Ovarian cancer is a lethal gynecologic malignancy that may benefit from new therapies that
block key paracrine pathways involved in tumor-stromal interactions and tumor vascularity. It …

Recent findings on the molecular basis of ovarian cancer development and progression
create new opportunities to develop anticancer medications that would affect specific …

The cure rate for women with ovarian cancer has not significantly changed over the past 10
years. However, overall survival from relapsed disease has shown improvement despite a …