Lynch syndrome is a hereditary cancer syndrome caused by germline mutations in one of
several DNA mismatch repair genes. Lynch syndrome leads to an increased lifetime risk of …

Lynch syndrome (LS) is the most common hereditary colorectal cancer (CRC) predisposition
syndrome. We performed a large‐scale study to assess a screening strategy for identifying …

METHODS: We searched the provincial pathology database with “adenocarcinoma” in the
colorectal specimen pathology reports between March 2018 and December 2020. We cross …

Background & Aims The province of Ontario, Canada is considering immunohistochemical
followed by cascade analyses of all patients who received a diagnosis of colorectal cancer …

Background People at risk of developing hereditary cancers associated with Lynch
Syndrome (LS) can be identified through universal screening of colorectal tumors. However …

Background A large proportion of patients with Lynch syndrome (LS) have MSH2
abnormalities, but genotype-phenotype studies of MSH2 mutations in LS are still lacking …

Background Genetic testing for hereditary cancer susceptibility has advanced over time due
to the discovery of new risk genes, improved technology and decreased cost. In the province …

Despite clinical guidelines, programs conducting population‐based screening and genetic
service delivery for hereditary cancer prevention and control are rare in practice. We …

Lynch syndrome (LS) is the most common cause of hereditary colorectal cancer (CRC);
however, it is still underrecognized and underdiagnosed. While international guidelines …

Abstract Background Deficiencies in Mismatch Repair (MMR) proteins are one of the major
pathways in the development of colorectal cancer (CRC). MMR status evaluation is …