Emergence of HIV drug resistance during first-and second-line antiretroviral therapy in resource-limited settings

MC Hosseinipour, RK Gupta, G Van Zyl… - The Journal of …, 2013 - academic.oup.com
Introduction Antiretroviral therapy (ART) in resource-limited settings has expanded in the last
decade, reaching> 8 million individuals and reducing AIDS mortality and morbidity …

Effectiveness of protease inhibitor/nucleos (t) ide reverse transcriptase inhibitor–based second-line antiretroviral therapy for the treatment of human immunodeficiency …

AJ Stockdale, MJ Saunders, MA Boyd… - Clinical infectious …, 2018 - academic.oup.com
Abstract Background In sub-Saharan Africa, 25.5 million people are living with human
immunodeficiency virus (HIV), representing 70% of the global total. The need for second-line …

HIV-1 second-line failure and drug resistance at high-level and low-level viremia in Western Kenya

R Kantor, A DeLong, L Schreier, M Reitsma, E Kemboi… - Aids, 2018 - journals.lww.com
Objective: Characterize failure and resistance above and below guidelines-recommended
1000 copies/ml virologic threshold, upon second-line failure. Design: Cross-sectional study …

HIV-1 drug resistance and third-line therapy outcomes in patients failing second-line therapy in Zimbabwe

C Chimbetete, D Katzenstein, T Shamu… - Open forum …, 2018 - academic.oup.com
Objectives To analyze the patterns and risk factors of HIV drug resistance mutations among
patients failing second-line treatment and to describe early treatment responses to …

Factors associated with the development of drug resistance mutations in HIV-1 infected children failing protease inhibitor-based antiretroviral therapy in South Africa

TM Rossouw, UD Feucht, G Melikian, G Van Dyk… - PloS one, 2015 - journals.plos.org
Objective Limited data are available from the developing world on antiretroviral drug
resistance in HIV-1 infected children failing protease inhibitor-based antiretroviral therapy …

[HTML][HTML] Prevalence and factors associated with HIV-1 drug resistance mutations in treatment-experienced patients in Nairobi, Kenya: A cross-sectional study

YA Scriven, MM Mulinge, N Saleri, EA Luvai… - Medicine, 2021 - journals.lww.com
An estimated 1.5 million Kenyans are HIV-seropositive, with 1.1 million on antiretroviral
therapy (ART), with the majority of them unaware of their drug resistance status. In this study …

Accumulation of protease mutations among patients failing second-line antiretroviral therapy and response to salvage therapy in Nigeria

HE Rawizza, B Chaplin, ST Meloni, KM Darin… - PloS one, 2013 - journals.plos.org
Background To date, antiretroviral therapy (ART) guidelines and programs in resource-
limited settings (RLS) have focused on 1st-and 2nd-line (2 L) therapy. As programs …

[PDF][PDF] The evolving landscape of HIV drug resistance diagnostics for expanding testing in resource-limited settings

SC Inzaule, RL Hamers, R Paredes, C Yang… - AIDS Rev, 2017 - researchgate.net
Global scale-up of antiretroviral treatment has dramatically changed the prospects of
HIV/AIDS disease, rendering life-long chronic care and treatment a reality for millions of HIV …

Implementation of an intensive adherence intervention in patients with second-line antiretroviral therapy failure in four west African countries with little access to …

SP Eholie, R Moh, A Benalycherif, D Gabillard… - The Lancet …, 2019 - thelancet.com
Background The decision about whether to switch to third-line antiretroviral therapy (ART) in
patients with treatment failure on second-line therapy is difficult in settings with little access …

Laboratory Based Surveillance of HIV-1 Acquired Drug Resistance in Cameroon: Implications for Use of Tenofovir-Lamivudine-Dolutegravir (TLD) as Second-or Third …

J Fokam, CA Chenwi, D Takou, MM Santoro, V Tala… - Viruses, 2023 - mdpi.com
Increased HIV drug resistance (HIVDR) with antiretroviral therapy (ART) rollout may
jeopardize therapeutic options, especially in this era of transition to fixed-dose tenofovir …