The function of the mammalian heart depends on the interplay between different cardiac cell
types. The deployment of these cells, with precise spatiotemporal regulation, is also …

The cardiac conduction system (CCS) consists of distinctive components that initiate and
conduct the electrical impulse required for the coordinated contraction of the cardiac …

The heart is the first organ to be functional in the fetus. Heart formation is a complex
morphogenetic process regulated by both genetic and epigenetic mechanisms. Congenital …

Extensive studies have shown how bilateral symmetry of the vertebrate embryo is broken
during early development, resulting in a molecular left-right bias in the mesoderm. However …

Congenital heart disease is the most frequent birth defect and the leading cause of death for
the fetus and in the first year of life. The wide phenotypic diversity of congenital heart defects …

The rate and rhythm of heart muscle contractions are coordinated by the cardiac conduction
system (CCS), a generic term for a collection of different specialized muscular tissues within …

Most animals show external bilateral symmetry, which hinders the observation of multiple
internal left–right (L/R) asymmetries that are fundamental to organ packaging and function …

Retinoic acid (RA) signaling plays an important role during heart development in
establishing anteroposterior polarity, formation of inflow and outflow tract progenitors, and …

Neck muscles constitute a transition zone between somite-derived skeletal muscles of the
trunk and limbs, and muscles of the head, which derive from cranial mesoderm. The …

How left-right patterning drives asymmetric morphogenesis is unclear. Here, we have
quantified shape changes during mouse heart looping, from 3D reconstructions by HREM. In …