A small group of specialized myocardial cells constitutes a natural dominant heart
pacemaker in the so-called sinoatrial node (SAN). The SAN determines proper heart …

The cardiac conduction system (CCS) initiates and coordinately propagates the electrical
impulse to orchestrate the heartbeat. It consists of a set of interconnected components with …

斑马鱼(Danio rerio) 转录因子hoxb4a 在心脏中的功能未见研究报道, 为了阐明hoxb4a
在心脏发育中的作用, 利用基因沉默技术和mRNA 基因过表达方法, 分别在斑马鱼中敲降和过 …

Smoothened is a key receptor of the hedgehog pathway, but the roles of Smoothened in
cardiac development remain incompletely understood. In this study, we found that the …

Cell fate specification is a critical process to generate cells with a wide range of
characteristics from stem and progenitor cells. Emerging evidence demonstrates that the …

Specialized myocytes of the cardiac conduction system (CCS) are essential to coordinate
sequential contraction of cardiac atria and ventricles. Anomalies of the CCS can result in …

As other tubular organs, the embryonic heart develops from an epithelial sheet of cells,
referred to as the heart field. The second heart field, which lies in the dorsal pericardial wall …

Myocardial cells ensure the contractility of the heart, which also depends on other
mesodermal cell types for its function. Embryological experiments had identified the sources …

The heart forms from the first and second heart fields which contribute to distinct regions of
the myocardium. This is supported by clonal analyses which identify corresponding first and …

How organ laterality is established during embryo development is an intriguing question that
remains largely unresolved. By using morpholino-based knockdown and CRISPR–Cas9 …