This review provides insight into the role of engineered T-cell receptors (TCRs) in
immunotherapy. Novel approaches have been developed to boost anticancer immune …

Advances in cell-based therapy, particularly CAR-T cell therapy, have transformed the
treatment of hematological malignancies. Although an important step forward for the field …

Cytokine-inducible SH2-containing protein (CIS; encoded by the gene CISH) is a key
negative regulator of interleukin-15 (IL-15) signaling in natural killer (NK) cells. Here, we …

Antibody-dependent cellular cytotoxicity (ADCC) is a key effector mechanism of natural killer
(NK) cells that is mediated by therapeutic monoclonal antibodies (mAbs). This process is …

Neutrophils, the most abundant white blood cells in circulation, are closely related to cancer
development and progression. Healthy primary neutrophils present potent cytotoxicity …

Human natural killer (NK) cell-based adoptive anticancer immunotherapy has gained
intense interest with many clinical trials actively recruiting patients to treat a variety of both …

Simple Summary Induced pluripotent stem cells (iPSCs) that can be genetically engineered
and differentiated into different types of immune cells, providing an unlimited resource for …

Induced pluripotent stem cells (iPSC) technology has propelled the field of stem cells
biology, providing new cells to explore the molecular mechanisms of pluripotency, cancer …

Natural killer (NK) cells derived or isolated from different sources have been gaining in
importance for cancer therapies. In this study, we evaluate and compare key characteristics …

Abstract Introduction Pluripotent stem cells (PSCs) are promising tools for modern
regenerative medicine applications because of their stemness properties, which include …