Sleep deprivation is highly prevalent in the modern world, possibly reaching epidemic
proportions. While multiple theories regarding the roles of sleep exist (inactivity, energy …

As the population of older adults grows, so will the prevalence of aging-related conditions,
including memory impairments and sleep disturbances, both of which are more common …

Sleep is a vital and evolutionarily conserved process, critical to daily functioning and
homeostatic balance. Losing sleep is inherently stressful and leads to numerous detrimental …

Background Soluble amyloid-beta oligomers (Aβo) begin to accumulate in the human brain
one to two decades before a clinical diagnosis of Alzheimer's disease (AD). The literature …

Withdrawal symptoms are observed upon cessation of cannabis use in humans. Although
animal studies have examined withdrawal symptoms following exposure to delta-9 …

Background Rhynchophylline (RHY) is an alkaloid component of Uncaria, which are plants
extensively used in traditional Asian medicines. Uncaria treatments increase sleep time and …

Multiple studies have documented sex differences in sleep behaviour, however, the
molecular determinants of such differences remain unknown. Furthermore, most studies …

Thirst is an essential motivational component that could modulate the strength of
conditioning; pioneer studies show that the rats' sexual dimorphism observed in the rate of …

Abstract Narcolepsy Type 1 (NT1), a sleep disorder with similar prevalence in both sexes, is
thought to be due to loss of the hypocretin/orexin (Hcrt) neurons. Several transgenic strains …

Circadian rhythms originate from molecular feedback loops. In mammals, the transcription
factors CLOCK and BMAL1 act on regulatory elements (ie E-boxes) to shape biological …