Pathogenesis of autoimmune disease
DS Pisetsky - Nature Reviews Nephrology, 2023 - nature.com
Autoimmune diseases are a diverse group of conditions characterized by aberrant B cell
and T cell reactivity to normal constituents of the host. These diseases occur widely and …
and T cell reactivity to normal constituents of the host. These diseases occur widely and …
Epidemiology and risk of cardiovascular disease in populations with chronic kidney disease
Chronic kidney disease (CKD) is defined by a low glomerular filtration rate or high
albuminuria, and affects 15–20% of adults globally. CKD increases the risk of various …
albuminuria, and affects 15–20% of adults globally. CKD increases the risk of various …
Inaxaplin for Proteinuric Kidney Disease in Persons with Two APOL1 Variants
O Egbuna, B Zimmerman, G Manos… - … England Journal of …, 2023 - Mass Medical Soc
Background Persons with toxic gain-of-function variants in the gene encoding
apolipoprotein L1 (APOL1) are at greater risk for the development of rapidly progressive …
apolipoprotein L1 (APOL1) are at greater risk for the development of rapidly progressive …
APOL1 risk variants affect podocyte lipid homeostasis and energy production in focal segmental glomerulosclerosis
Lipotoxicity was recently reported in several forms of kidney disease, including focal
segmental glomerulosclerosis (FSGS). Susceptibility to FSGS in African Americans is …
segmental glomerulosclerosis (FSGS). Susceptibility to FSGS in African Americans is …
Importance of diversity in precision medicine: Generalizability of genetic associations across ancestry groups toward better identification of disease susceptibility …
LA Cruz, JN Cooke Bailey… - Annual review of …, 2023 - annualreviews.org
Genome-wide association studies (GWAS) revolutionized our understanding of common
genetic variation and its impact on common human disease and traits. Developed and …
genetic variation and its impact on common human disease and traits. Developed and …
Apolipoprotein L1 (APOL1) renal risk variant-mediated podocyte cytotoxicity depends on African haplotype and surface expression
N Gupta, B Waas, D Austin, AM De Mazière… - Scientific Reports, 2024 - nature.com
Abstract Homozygous Apolipoprotein L1 (APOL1) variants G1 and G2 cause APOL1-
mediated kidney disease, purportedly acting as surface cation channels in podocytes …
mediated kidney disease, purportedly acting as surface cation channels in podocytes …
[HTML][HTML] Retaining race in chronic kidney disease diagnosis and treatment
P Williams - Cureus, 2023 - ncbi.nlm.nih.gov
The best overall measure of kidney function is glomerular filtration rate (GFR) as commonly
estimated from serum creatinine concentrations (eGFR cr) using formulas that correct for the …
estimated from serum creatinine concentrations (eGFR cr) using formulas that correct for the …
Cholesterol transport and beyond: Illuminating the versatile functions of HDL apolipoproteins through structural insights and functional implications
High‐density lipoproteins (HDLs) play a vital role in lipid metabolism and cardiovascular
health, as they are intricately involved in cholesterol transport and inflammation modulation …
health, as they are intricately involved in cholesterol transport and inflammation modulation …
Idiopathic collapsing glomerulopathy is associated with APOL1 high-risk genotypes or Mendelian variants in most affected individuals in a highly admixed population
PD Neves, A Watanabe, EH Watanabe, AM Narcizo… - Kidney International, 2024 - Elsevier
Collapsing glomerulopathy (CG) is most often associated with fast progression to kidney
failure with an incidence apparently higher in Brazil than in other countries. However, the …
failure with an incidence apparently higher in Brazil than in other countries. However, the …
Mapping the serum proteome of COVID-19 patients; guidance for severity assessment
E Nuñez, I Orera, L Carmona-Rodríguez, JR Paño… - Biomedicines, 2022 - mdpi.com
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), whose outbreak in 2019 led to an ongoing pandemic with …
coronavirus 2 (SARS-CoV-2), whose outbreak in 2019 led to an ongoing pandemic with …