Huntington's disease (HD) is a neurodegenerative disorder caused by an autosomal
dominant mutation leading to an abnormal CAG repeat expansion. The result is the …

Several diseases of the central nervous system are age-associated and do not directly result
from genetic mutations. These include late-onset neurodegenerative diseases (NDDs) …

Inherited retinal dystrophies comprise a broad group of genetic eye diseases without
effective treatment. Among them, Stargardt disease is the second most prevalent pathology …

Parkinson's disease (PD) is one of the most common degenerative diseases. It is most
typically characterized by neuronal death following the accumulation of Lewis inclusions in …

The evolutionary conserved WNT signaling pathway orchestrates numerous complex
biological processes during development and is critical to the maintenance of tissue integrity …

Amyotrophic lateral sclerosis (ALS) is a deadly neurological disease with a complicated and
variable pathophysiology yet to be fully understood. There is currently no effective treatment …

Background: Motor neuron diseases (MNDs) are progressive neurodegenerative disorders
characterized by motor impairment and non-motor symptoms. The involvement of the …

The genetic landscape of neurodegenerative diseases encompasses genes affecting
multiple cellular pathways which exert effects in an array of neuronal and glial cell-types …

Neurodegenerative diseases (NDD) are characterized by the gradual deterioration of
neuronal function and integrity, resulting in an overall decline in brain function. The existing …

Neurodegenerative diseases are increasing in prevalence and comprise a large
socioeconomic burden on patients and their caretakers. The need for effective therapies and …