Sepsis remains a major cause of morbidity and mortality in both low-and high-income
countries. Antibiotic therapy and supportive care have significantly improved survival …

OBJECTIVES: To identify research priorities in the management, epidemiology, outcome,
and pathophysiology of sepsis and septic shock. DESIGN: Shortly after publication of the …

Neutrophil extracellular traps (NETs), released by polymorphonuclear neutrophils (PMNs),
exert a robust antimicrobial function in infectious diseases such as sepsis. NETs also …

Liver injury and progressive liver failure are severe life-threatening complications in sepsis,
further worsening the disease and leading to death. Macrophages and their mediated …

Innate immune cells play essential roles in modulating both immune defense and
inflammation by expressing a diverse array of cytokines and inflammatory mediators …

Background Sepsis is a severe systemic inflammatory disorder manifested by a
dysregulated immune response to infection and multi-organ failure. Numerous studies have …

Excessive immune activation and immunosuppression are opposing factors that contribute
to the dysregulated innate and adaptive immune responses seen in severe inflammation …

Corneal diseases are among the primary causes of blindness and vision loss worldwide.
However, the pathogenesis of corneal diseases remains elusive, and diagnostic and …

Immune cells and immunity are associated with the prognosis of patients with critical illness.
Here, medical records retrospectively extracted from the Medical Information Mart for …

Macrophage dysfunction is a significant contributor to more than 70% of sepsis-related
deaths, specifically secondary bacterial infections, during the immunosuppression stage of …