Due to their efficient recognition and lysis of malignant cells, natural killer (NK) cells are
considered as specialized immune cells that can be genetically modified to obtain capable …

Natural killer (NK) cells are unique immune effectors able to kill cancer cells by direct
recognition of surface ligands, without prior sensitization. Allogeneic NK transfer is a highly …

Background Several commercial and academic autologous chimeric antigen receptor T-cell
(CAR-T) products targeting CD19 have been approved in Europe for relapsed/refractory B …

Background Glypican-3 (GPC-3) is an oncofetal protein that is highly expressed in various
solid tumors, but rarely expressed in healthy adult tissues and represents a rational target of …

Glioblastoma (GB) is the most common and aggressive primary brain tumor in adults and
currently incurable. Despite multimodal treatment regimens, median survival in unselected …

Cell-based immunotherapy has become the new-generation cancer medicine, and" off-the-
shelf" cell products that can be manufactured at large scale and distributed readily to treat …

Cryopreservation is a key enabling technology in regenerative medicine that provides stable
and secure extended cell storage for primary tissue isolates and constructs and prepared …

γδ T cells have recently gained considerable attention as an attractive tool for cancer
adoptive immunotherapy due to their potent anti-tumor activity and unique role in …

Introduction Most breast cancer-related deaths arise from triple-negative breast cancer
(TNBC). Molecular heterogeneity, aggressiveness and the lack of effective therapies are …

Adoptive immunotherapies based on the transfer of functional immune cells hold great
promise in treating a wide range of malignant diseases, especially cancers, autoimmune …