Sialidase inhibitors with different mechanisms

JM Keil, GR Rafn, IM Turan, MA Aljohani… - Journal of medicinal …, 2022 - ACS Publications
Sialidases, or neuraminidases, are enzymes that catalyze the hydrolysis of sialic acid (Sia)-
containing molecules, mostly removal of the terminal Sia (desialylation). By desialylation …

[HTML][HTML] The elastin receptor complex: An emerging therapeutic target against age-related vascular diseases

D Tembely, A Henry, L Vanalderwiert… - Frontiers in …, 2022 - frontiersin.org
The incidence of cardiovascular diseases is increasing worldwide with the growing aging of
the population. Biological aging has major influence on the vascular tree and is associated …

Human neuraminidases: Structures and stereoselective inhibitors

E Bourguet, S Figurska… - Journal of Medicinal …, 2022 - ACS Publications
This Perspective describes the classification, structures, substrates, mechanisms of action,
and implications of human neuraminidases (hNEUs) in various pathologies. Some inhibitors …

[HTML][HTML] The role of sialidase Neu1 in respiratory diseases

S Mei, D Li, A Wang, G Zhu, B Zhou, N Li, Y Qin… - Respiratory …, 2024 - Springer
Neu1 is a sialidase enzyme that plays a crucial role in the regulation of glycosylation in a
variety of cellular processes, including cellular signaling and inflammation. In recent years …

[HTML][HTML] Neuraminidase-1: a sialidase involved in the development of cancers and metabolic diseases

K Toussaint, A Appert-Collin, H Morjani, C Albrecht… - Cancers, 2022 - mdpi.com
Simple Summary Cancers and metabolic diseases represent a leading cause of death in
both developing and developed countries. Thus, new diagnostic and prognostic targets are …

[HTML][HTML] Inhibition of neuraminidase-1 sialidase activity by interfering peptides impairs insulin receptor activity in vitro and glucose homeostasis in vivo

K Toussaint, A Appert-Collin, L Vanalderwiert… - Journal of Biological …, 2024 - Elsevier
Neuraminidases also called sialidases are glycosidases which catalyze the removal of
terminal sialic acid residues from glycoproteins, glycolipids and oligosaccharides …

Chemical constituents from Ficus tikoua and chemotaxonomic significance

HL Wang, J Lu, XL Chen, R Li, K Zhang, YL Guo… - Biochemical Systematics …, 2024 - Elsevier
The phytochemical composition of Ficus tikoua Bur. was studied, from which fourteen
compounds were isolated, including four phenolics (1-4), one aromatic alcohol glycoside …