[HTML][HTML] Radial glia and radial glia-like cells: Their role in neurogenesis and regeneration

Y Miranda-Negrón, JE García-Arrarás - Frontiers in Neuroscience, 2022 - frontiersin.org
Radial glia is a cell type traditionally associated with the developing nervous system,
particularly with the formation of cortical layers in the mammalian brain. Nonetheless, some …

Blood vessels as a scaffold for neuronal migration

T Fujioka, N Kaneko, K Sawamoto - Neurochemistry international, 2019 - Elsevier
Neurogenesis and angiogenesis share regulatory factors that contribute to the formation of
vascular networks and neuronal circuits in the brain. While crosstalk mechanisms between …

Coaxial 3D printing of hierarchical structured hydrogel scaffolds for on-demand repair of spinal cord injury

Y Li, S Cheng, H Wen, L Xiao, Z Deng, J Huang… - Acta Biomaterialia, 2023 - Elsevier
After spinal cord injury (SCI), endogenous neural stem cells (NSCs) near the damaged site
are activated, but few NSCs migrate to the injury epicenter and differentiate into neurons …

A functional scaffold to promote the migration and neuronal differentiation of neural stem/progenitor cells for spinal cord injury repair

W Liu, B Xu, W Xue, B Yang, Y Fan, B Chen, Z Xiao… - Biomaterials, 2020 - Elsevier
After spinal cord injury (SCI), endogenous neural/progenitor stem cells (NSPCs) were
activated in neural tissue adjacent to the injured segment, but few cells migrated to the injury …

Structural alignment guides oriented migration and differentiation of endogenous neural stem cells for neurogenesis in brain injury treatment

Y Chai, H Zhao, S Yang, X Gao, Z Cao, J Lu, Q Sun… - Biomaterials, 2022 - Elsevier
Radial glia (RG) cells that align in parallel in the embryonic brain are found to be able to
guide the directed migration of neurons in response to brain injury. Therefore, biomaterials …

[HTML][HTML] Identification of the growth cone as a probe and driver of neuronal migration in the injured brain

C Nakajima, M Sawada, E Umeda, Y Takagi… - Nature …, 2024 - nature.com
Axonal growth cones mediate axonal guidance and growth regulation. We show that
migrating neurons in mice possess a growth cone at the tip of their leading process, similar …

Harnessing developmental dynamics of spinal cord extracellular matrix improves regenerative potential of spinal cord organoids

Z Sun, Z Chen, M Yin, X Wu, B Guo, X Cheng, R Quan… - Cell Stem Cell, 2024 - cell.com
Neonatal spinal cord tissues exhibit remarkable regenerative capabilities as compared to
adult spinal cord tissues after injury, but the role of extracellular matrix (ECM) in this process …

Neuraminidase inhibition promotes the collective migration of neurons and recovery of brain function

M Matsumoto, K Matsushita, M Hane… - EMBO Molecular …, 2024 - embopress.org
In the injured brain, new neurons produced from endogenous neural stem cells form chains
and migrate to injured areas and contribute to the regeneration of lost neurons. However …

Amphiphilic peptide-tagged N-cadherin forms radial glial-like fibers that enhance neuronal migration in injured brain and promote sensorimotor recovery

Y Ohno, C Nakajima, I Ajioka, T Muraoka, A Yaguchi… - Biomaterials, 2023 - Elsevier
The mammalian brain has very limited ability to regenerate lost neurons and recover
function after injury. Promoting the migration of young neurons (neuroblasts) derived from …

[HTML][HTML] The potential of mechanistic information organised within the AOP framework to increase regulatory uptake of the developmental neurotoxicity (DNT) in vitro …

M Sachana, C Willett, F Pistollato, A Bal-Price - Reproductive Toxicology, 2021 - Elsevier
A major challenge in regulatory developmental neurotoxicity (DNT) assessment is lack of
toxicological information for many compounds. Therefore, the Test Guidelines programme of …