Tissue-specific macrophages: how they develop and choreograph tissue biology
Macrophages are innate immune cells that form a 3D network in all our tissues, where they
phagocytose dying cells and cell debris, immune complexes, bacteria and other waste …
phagocytose dying cells and cell debris, immune complexes, bacteria and other waste …
Role of neuroinflammation in neurodegeneration development
Studies in neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease
and Amyotrophic lateral sclerosis, Huntington's disease, and so on, have suggested that …
and Amyotrophic lateral sclerosis, Huntington's disease, and so on, have suggested that …
Cancer neuroscience: State of the field, emerging directions
The nervous system governs both ontogeny and oncology. Regulating organogenesis
during development, maintaining homeostasis, and promoting plasticity throughout life, the …
during development, maintaining homeostasis, and promoting plasticity throughout life, the …
Alzheimer's disease: From immunotherapy to immunoprevention
M Jucker, LC Walker - Cell, 2023 - cell.com
Recent Aβ-immunotherapy trials have yielded the first clear evidence that removing
aggregated Aβ from the brains of symptomatic patients can slow the progression of …
aggregated Aβ from the brains of symptomatic patients can slow the progression of …
Circulating myeloid-derived MMP8 in stress susceptibility and depression
Psychosocial stress has profound effects on the body, including the immune system and the
brain,. Although a large number of pre-clinical and clinical studies have linked peripheral …
brain,. Although a large number of pre-clinical and clinical studies have linked peripheral …
Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases
The human gastrointestinal tract is populated with a diverse microbial community. The vast
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …
Boundaries and integration between microbiota, the nervous system, and immunity
AJ Macpherson, V Pachnis, M Prinz - Immunity, 2023 - cell.com
The enteric nervous system is largely autonomous, and the central nervous system is
compartmentalized behind the blood-brain barrier. Yet the intestinal microbiota shapes gut …
compartmentalized behind the blood-brain barrier. Yet the intestinal microbiota shapes gut …
Current understanding of the anatomy, physiology, and magnetic resonance imaging of neurofluids: update from the 2022 “ISMRM Imaging Neurofluids Study group” …
Neurofluids is a term introduced to define all fluids in the brain and spine such as blood,
cerebrospinal fluid, and interstitial fluid. Neuroscientists in the past millennium have steadily …
cerebrospinal fluid, and interstitial fluid. Neuroscientists in the past millennium have steadily …
Immaturity of immune cells around the dural venous sinuses contributes to viral meningoencephalitis in neonates
High neonatal susceptibility to meningitis has been attributed to the anatomical barriers that
act to protect the central nervous system (CNS) from infection being immature and not fully …
act to protect the central nervous system (CNS) from infection being immature and not fully …
Osteocyte-derived sclerostin impairs cognitive function during ageing and Alzheimer's disease progression
Ageing increases susceptibility to neurodegenerative disorders, such as Alzheimer's
disease (AD). Serum levels of sclerostin, an osteocyte-derived Wnt–β-catenin signalling …
disease (AD). Serum levels of sclerostin, an osteocyte-derived Wnt–β-catenin signalling …