Novel triazole-quinoline derivatives as selective dual binding site acetylcholinesterase inhibitors

SP Mantoani, TPC Chierrito, AFL Vilela, CL Cardoso… - Molecules, 2016 - mdpi.com
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder worldwide.
Currently, the only strategy for palliative treatment of AD is to inhibit acetylcholinesterase …

From dual binding site acetylcholinesterase inhibitors to allosteric modulators: A new avenue for disease-modifying drugs in Alzheimer's disease

TPC Chierrito, S Pedersoli-Mantoani, C Roca… - European Journal of …, 2017 - Elsevier
The lack of an effective treatment for Alzheimer'disease (AD), an increasing prevalence and
severe neurodegenerative pathology boost medicinal chemists to look for new drugs …

The laccase-catalyzed domino reaction between catechols and heterocyclic 1, 3-dicarbonyls and the unambiguous structure elucidation of the products by NMR …

S Hajdok, J Conrad, H Leutbecher… - The Journal of …, 2009 - ACS Publications
The laccase-catalyzed reaction between catechols and heterocyclic 1, 3-dicarbonyls
(pyridinones, quinolinones, thiocoumarins) using aerial oxygen as the oxidant delivers …

Laccase-catalyzed phenol oxidation. Rapid assignment of ring-proton deficient polycyclic benzofuran regioisomers by experimental 1 H–13 C long-range coupling …

H Leutbecher, G Greiner, R Amann, A Stolz… - Organic & …, 2011 - pubs.rsc.org
Laccase-catalyzed oxidation of substituted catechols followed by reaction with 4-hydroxy-
pyrone/-benzopyrone afforded substituted benzofuran regioisomers whose structures with …

2JHH-resolved HSQC: Exclusive determination of geminal proton-proton coupling constants

N Marcó, P Nolis, RR Gil, T Parella - Journal of Magnetic Resonance, 2017 - Elsevier
The measurement of two-bond proton-proton coupling constants (2 J HH) in prochiral CH 2
groups from the F2 dimension of 2D spectra is not easy due to the usual presence of …

NMR property calculations and experimental study of the 1, 6‐epoxycarvone and α‐epoxypinene: a comparison of models

LHK Queiroz Jr, V Lacerda Jr… - Magnetic …, 2011 - Wiley Online Library
This work aims at using theoretical calculations of shielding tensors (σ) through different
methods [gauge‐independent atomic orbital (GIAO), continuous set of gauge …

Stereochemistry of cyclopentane derivatives from 2, 3JCH dependence on dihedral angle (θ HCCX)

V Lacerda Jr, GVJ da Silva… - Magnetic …, 2008 - Wiley Online Library
The 2, 3JCH dependence on dihedral angle (θ H C C X) for cyclopentane derivatives
was investigated. We observed that the combined use of experimentally obtained 2, 3JCH …

Estratégias de aumento de eficiência da análise de produtos naturais por espectroscopia de ressonância magnética nuclear

ED Rodrigues - 2010 - teses.usp.br
Dois dos principais aspectos da Química de Produtos Naturais são a identificação e a
determinação estrutural dos compostos orgânicos presentes em materiais de origem …

Applications of spin–spin coupling

K Kamieńska-Trela, J Wójcik - 2008 - books.rsc.org
Applications of spin–spin coupling | Nuclear Magnetic Resonance | Books Gateway | Royal
Society of Chemistry Skip to Main Content Umbrella Alt Text Umbrella Alt Text Close …

A urea‐linked glucosamine dimer as a building block for the synthesis of linear and cyclic neosaccharides

L Cirillo, A Silipo, E Bedini, M Parrilli - 2010 - Wiley Online Library
A novel urea‐linked glucosamine dimer was obtained through a modification of the standard
oxazolidinone closure reaction on a 2, 3‐amino alcohol monomer and fully characterized by …