To cope with DNA double strand break (DSB) genotoxicity, cells have evolved two main
repair pathways: homologous recombination which uses homologous DNA sequences as …

Twenty years ago, the first familial melanoma susceptibility gene, CDKN 2A, was identified.
Two years later, another high‐penetrance gene, CDK 4, was found to be responsible for …

Mammalian CST (CTC1‐STN1‐TEN1) associates with telomeres and depletion of CTC1 or
STN1 causes telomere defects. However, the function of mammalian CST remains poorly …

Human telomeres bind shelterin, the six-subunit protein complex that protects chromosome
ends from the DNA damage response and regulates telomere length maintenance by …

The telomeres that cap the ends of eukaryotic chromosomes serve a dual role in protecting
the chromosome ends and in intracellular signaling for regulating cell proliferation. A …

Abstract The Nobel Prize in Physiology or Medicine was recently awarded to Elizabeth
Blackburn, Carol Greider and Jack Szostak for their pioneering studies on chromosome …

Telomerase reverse transcribes short guanine (G)-rich DNA repeat sequences from its
internal RNA template to maintain telomere length. G-rich telomere DNA repeats readily fold …

Telomerase is unique among the reverse transcriptases in containing a noncoding RNA
(known as telomerase RNA (TER)) that includes a short template that is used for the …

The POT1 (protection of telomeres) protein binds the single‐stranded G‐rich overhang and
is essential for both telomere end protection and telomere length regulation. Telomeric …

Chronic lymphocytic leukemia (CLL) can be familial; however, thus far no rare germ line
disruptive alleles for CLL have been identified. We performed whole-exome sequencing of …