Cellular purine nucleotides derive mainly from de novo synthesis or nucleic acid turnover
and, only marginally, from dietary intake. They are subjected to catabolism, eventually …

As a cytosolic enzyme involved in the purine salvage pathway metabolism, purine
nucleoside phosphorylase (PNP) plays an important role in a variety of cellular functions but …

Abstract Idiopathic Granulomatous Mastitis (IGM) is a disease that clinically mimics breast
cancers with symptoms of pain, edema, erythema, nipple discharge, nipple retraction, and …

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by
synovial inflammation and joint damage with complex pathological mechanisms. In recent …

Autoimmunity has long been regarded as the polar opposite of immunodeficiency, but
clinical and experimental evidence refute this notion. Indeed, numerous inborn or acquired …

Many research groups and institutions have created a variety of databases curating
experimental and predicted data related to protein-ligand binding. The landscape of …

Background Purine nucleoside phosphorylase (PNP) deficiency is a rare autosomal
recessive combined immunodeficiency. The phenotype is profound T cell deficiency with …

Purines and pyrimidines are essential components as they are the building blocks of vital
molecules, such as nucleic acids, coenzymes, signalling molecules, as well as energy …

Two Iranian patients with purine nucleoside phosphorylase (PNP) deficiency are described
in terms of their clinical and molecular evaluations. PNP deficiency is a rare form of …

Purine nucleoside phosphorylase deficient severe combined immunodeficiency (PNP SCID)
is one of the rare autosomal recessive primary immunodeficiency disease, and the data on …