Adenosine 5′-triphosphate acts as an extracellular signalling molecule (purinergic
signalling), as well as an intracellular energy source. Adenosine 5′-triphosphate receptors …

The heart is uniquely responsible for providing its own blood supply through the coronary
circulation. Regulation of coronary blood flow is quite complex and, after over 100 years of …

P2X receptors are membrane ion channels that open in response to the binding of
extracellular ATP. Seven genes in vertebrates encode P2X receptor subunits, which are 40 …

Evidence from both experimental and clinical trials indicates that inflammatory mediators are
of importance in the pathogenesis of chronic heart failure (HF) contributing to cardiac …

The involvement of extracellular nucleotides and adenosine in an array of cell-specific
responses has long been known and appreciated, but the integrative view of purinergic …

There have been many advances in our knowledge about different aspects of P2Y receptor
signaling since the last review published by our International Union of Pharmacology …

Cardiovascular regenerative therapies are pursued on both basic and translational levels.
Although efficacy and value of cell therapy for myocardial regeneration can be debated …

Aims N ucleotide-binding oligomerization domain-L ike R eceptor with a P yrin domain 3
(NLRP3) is considered necessary for initiating a profound sterile inflammatory response …

The concept of a purinergic signaling system, using purine nucleotides and nucleosides as
extracellular messengers, was first proposed over 30 years ago. After a brief introduction …

The role of ATP as an extracellular signalling molecule is now well established and
evidence is accumulating that ATP and other nucleotides (ADP, UTP and UDP) play …