[HTML][HTML] 3′-end processing of eukaryotic mRNA: machinery, regulation, and impact on gene expression
V Boreikaitė, LA Passmore - Annual review of biochemistry, 2023 - annualreviews.org
Formation of the 3′ end of a eukaryotic mRNA is a key step in the production of a mature
transcript. This process is mediated by a number of protein factors that cleave the pre …
transcript. This process is mediated by a number of protein factors that cleave the pre …
Tales of detailed poly (A) tails
AL Nicholson, AE Pasquinelli - Trends in cell biology, 2019 - cell.com
Poly (A) tails are non-templated additions of adenosines at the 3′ ends of most eukaryotic
mRNAs. In the nucleus, these RNAs are co-transcriptionally cleaved at a poly (A) site and …
mRNAs. In the nucleus, these RNAs are co-transcriptionally cleaved at a poly (A) site and …
Engineered nucleic acids encoding a modified erythropoietin and their expression
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Formation of mRNA 3′ ends in eukaryotes: mechanism, regulation, and interrelationships with other steps in mRNA synthesis
J Zhao, L Hyman, C Moore - Microbiology and molecular biology …, 1999 - Am Soc Microbiol
Formation of mRNA 3′ ends in eukaryotes requires the interaction of transacting factors
with cis-acting signal elements on the RNA precursor by two distinct mechanisms, one for …
with cis-acting signal elements on the RNA precursor by two distinct mechanisms, one for …
[HTML][HTML] The poly (A)-binding protein nuclear 1 suppresses alternative cleavage and polyadenylation sites
Alternative cleavage and polyadenylation (APA) is emerging as an important layer of gene
regulation. Factors controlling APA are largely unknown. We developed a reporter-based …
regulation. Factors controlling APA are largely unknown. We developed a reporter-based …
Mechanism and regulation of mRNA polyadenylation
DF Colgan, JL Manley - Genes & development, 1997 - genesdev.cshlp.org
A poly (A) tail is found at the 3 end of nearly every fully processed eukaryotic mRNA and has
been suggested to influence virtually all aspects of mRNA metabolism. Its proposed …
been suggested to influence virtually all aspects of mRNA metabolism. Its proposed …
Terminally modified RNA
T Chakraborty, S Bancel, SG Hoge, A Roy… - US Patent …, 2017 - Google Patents
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[HTML][HTML] Poly (A)-binding proteins: multifunctional scaffolds for the post-transcriptional control of gene expression
DA Mangus, MC Evans, A Jacobson - Genome biology, 2003 - Springer
Most eukaryotic mRNAs are subject to considerable post-transcriptional modification,
including capping, splicing, and polyadenylation. The process of polyadenylation adds a …
including capping, splicing, and polyadenylation. The process of polyadenylation adds a …
Engineered nucleic acids and methods of use thereof
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C (= O) C (NC (= O)
C (CCC (N)= O) NC (= O) C (CCC (O)= O) NC (= O) C (C (C) C) NC (= O) C (NC (= O) CN) C …
C (CCC (N)= O) NC (= O) C (CCC (O)= O) NC (= O) C (C (C) C) NC (= O) C (NC (= O) CN) C …
Modified polynucleotides for the production of biologics and proteins associated with human disease
S Bancel, T Chakraborty, A De Fougerolles… - US Patent …, 2015 - Google Patents
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