Quercetin (QUR) is a natural bioactive flavonoid that has been lately very studied for its
beneficial properties in many pathologies. Its neuroprotective effects have been …

It has long been axiomatic that a protein's structure determines its function. Intrinsically
disordered proteins (IDPs) and disordered protein regions (IDRs) defy this structure …

Phosphorylation is the most common post-translational modification (PTM) in eukaryotes,
occurring particularly frequently in intrinsically disordered proteins (IDPs). These proteins …

We discuss protein post‐translational modification (PTM) from an information processing
perspective. PTM at multiple sites on a protein creates a combinatorial explosion in the …

Quercetin, a ubiquitous flavonoid that is widely distributed in plants is classified as a
cognitive enhancer in traditional and oriental medicine. The protective effects of quercetin for …

Protein misfolding and aggregation is a common hallmark in neurodegenerative disorders,
including Alzheimer's disease (AD), Parkinson's disease (PD), and fronto-temporal dementia …

Phosphorylation offers a dynamic way to regulate protein activity and subcellular
localization, which is achieved through its reversibility and fast kinetics. Adding or removing …

Gli proteins are transcriptional effectors of the Hedgehog (Hh) pathway in both normal
development and cancer. We describe a program of multisite phosphorylation that regulates …

Multisite phosphorylation modulates the function of regulatory proteins with complex
signaling properties and outputs. The retinoblastoma tumor suppressor protein (Rb) is …

Protein serine/threonine phosphatases (PPPs) are ancient enzymes, with distinct types
conserved across eukaryotic evolution. PPPs are segregated into types primarily on the …