OBJECTIVE: To summarize recent advances in the understanding of the endocrine
signaling pathways between the hypothalamus, pituitary, and human corpus luteum (CL); to …

The spectrum of vitamin D (VD)-mediated effects has expanded in recent years, and VD is
now recognized as a versatile signaling molecule rather than being solely a regulator of …

Studies using newer, potent GnRH antagonists and pure gonadotrophins have clarified the
importance of:(i) the strength-duration of the midcycle surge of pituitary gonadotrophins (LH …

Abstract Context: Progesterone (P4) inhibits human granulosa/luteal cell apoptosis by an
unknown mechanism. Objective: Our objective was to assess the role of the nuclear P4 …

Context: Progesterone (P4) promotes its own secretion and the survival of human
granulosa/luteal (GL) cells. Objective: The objective of these studies was to determine …

The main function of the corpus luteum (CL) is to synthesize and secrete progesterone (P4),
which regulates the duration of the estrous cycle and maintains of pregnancy in many …

Progesterone produced by the corpus luteum (CL) is a key regulator of normal cyclical
reproductive functions in the females of mammalian species. The physiological effects of …

The protein PAIRBP1, which was initially referred to as RDA288, is involved in mediating the
antiapoptotic action of progesterone (P4) in spontaneously immortalized granulosa cells …

Progesterone plays a central role in the regulation of ovarian function. The progesterone
receptor (PR) has been shown to be essential for ovulation because mice lacking PR fail to …

The human corpus luteum is a temporary endocrine gland that develops after ovulation from
the ruptured follicle during the luteal phase. It is an important contributor of steroid …