PKB/Akt–dependent regulation of cell motility
G Xue, BA Hemmings - Journal of the National Cancer Institute, 2013 - academic.oup.com
The prosurvival activity of phosphoinositide 3 kinase (PI3K)/Akt (also known as protein
kinase B, PKB) pathway has been investigated in great detail in human physiology and …
kinase B, PKB) pathway has been investigated in great detail in human physiology and …
The regulation of cell motility and chemotaxis by phospholipid signaling
V Kolsch, PG Charest, RA Firtel - Journal of cell science, 2008 - journals.biologists.com
Phosphoinositide 3-kinase (PI3K), PTEN and localized phosphatidylinositol (3, 4, 5)-
trisphosphate [PtdIns (3, 4, 5) P 3] play key roles in chemotaxis, regulating cell motility by …
trisphosphate [PtdIns (3, 4, 5) P 3] play key roles in chemotaxis, regulating cell motility by …
The E3 ligase TRIM16 is a key suppressor of pathological cardiac hypertrophy
J Liu, W Li, KQ Deng, S Tian, H Liu, H Shi… - Circulation …, 2022 - Am Heart Assoc
Background: Pathological cardiac hypertrophy is one of the leading causes of heart failure
with highly complicated pathogeneses. The E3 ligase TRIM16 (tripartite motif–containing …
with highly complicated pathogeneses. The E3 ligase TRIM16 (tripartite motif–containing …
AKT1 and AKT2 isoforms play distinct roles during breast cancer progression through the regulation of specific downstream proteins
M Riggio, MC Perrone, ML Polo, MJ Rodriguez… - Scientific reports, 2017 - nature.com
The purpose of this study was to elucidate the mechanisms associated with the specific
effects of AKT1 and AKT2 isoforms in breast cancer progression. We modulated the …
effects of AKT1 and AKT2 isoforms in breast cancer progression. We modulated the …
The insulin/Akt signaling pathway is targeted by intracellular β-amyloid
Intraneuronal β-amyloid (Aβi) accumulates early in Alzheimer's disease (AD) and inclusion
body myositis. Several organelles, receptor molecules, homeostatic processes, and signal …
body myositis. Several organelles, receptor molecules, homeostatic processes, and signal …
mTORC2 regulates mechanically induced cytoskeletal reorganization and lineage selection in marrow‐derived mesenchymal stem cells
B Sen, Z Xie, N Case, WR Thompson… - Journal of Bone and …, 2014 - academic.oup.com
The cell cytoskeleton interprets and responds to physical cues from the microenvironment.
Applying mechanical force to mesenchymal stem cells induces formation of a stiffer …
Applying mechanical force to mesenchymal stem cells induces formation of a stiffer …
Akt SUMOylation regulates cell proliferation and tumorigenesis
Proto-oncogene Akt plays essential roles in cell proliferation and tumorigenesis. Full
activation of Akt is regulated by phosphorylation, ubiquitination, and acetylation. Here we …
activation of Akt is regulated by phosphorylation, ubiquitination, and acetylation. Here we …
[HTML][HTML] MicroRNA-205 promotes keratinocyte migration via the lipid phosphatase SHIP2
Abstract microRNA-205 (miR-205) and miR-184 coordinately regulate the lipid phosphatase
SHIP2 for Akt survival signaling in keratinocytes. As the PI3K-Akt pathway has also been …
SHIP2 for Akt survival signaling in keratinocytes. As the PI3K-Akt pathway has also been …
[HTML][HTML] Nephrin mediates actin reorganization via phosphoinositide 3-kinase in podocytes
Nephrin is a slit diaphragm protein critical for structural and functional integrity of visceral
glomerular epithelial cells (podocytes) and is known to be tyrosine phosphorylated by Src …
glomerular epithelial cells (podocytes) and is known to be tyrosine phosphorylated by Src …