Early plants began colonizing the terrestrial earth approximately 450 million years ago. Their
success on land has been partially attributed to the evolution of specialized metabolic …

Background Aggregation of soluble, monomeric β-amyloid (Aβ) to oligomeric and then
insoluble fibrillar Aβ is a key pathogenic feature in development of Alzheimer's disease (AD) …

Epidemiological studies have suggested that diets rich in phenolic compounds may have
preventive effects on the development of dementia or Alzheimer's disease (AD). We …

Alzheimer disease (AD) is characterized by extracellular senile plaques, intracellular
neurofibrillary tangles, and memory loss. Aggregated amyloid-β (Aβ), oxidative stress, and …

Biflavonoids are divided in two classes: C–C type compounds represented by the dimeric
compound amentoflavone and C–O–C-type compounds typified by hinokiflavone (HNK) with …

Alzheimer's disease (AD) is neurodegenerative disease that occurs among the aging
population and is associated with impaired cognitive function. Amyloid-ß (Aß) oligomers …

In the course of studying the components from the roots of Sophora flavescens, eight new
unusual biflavonoids consisting of a flavanone fused with a dihydrochalcone skeleton were …

Growing evidence suggests that on-pathway amyloid-β (Aβ) oligomers are primary
neurotoxic species and have a direct correlation with the onset of Alzheimer's disease (AD) …

Inflammation and oxidative stress are common aspects of most neurodegenerative diseases
in the central nervous system. In this context, microglia and astrocytes are central to …

Deposition of fibrillar forms of amyloid β-protein (Aβ) is commonly found in patients with
Alzheimer's disease (AD) associated with cognitive decline. Impaired clearance of Aβ …