The first total syntheses of ochnaflavone, an asymmetric biflavone consisting of apigenin
and luteolin moieties, and the permethyl ether of 2, 3, 2'', 3''-tetrahydroochnaflavone have …

Beta-site amyloid precursor protein cleaving enzyme (BACE-1) is a well-known therapeutic
target for Alzheimer disease (AD) due to its characteristic role in the pathogenesis of AD …

Extracellular plaques, the hallmark of Alzheimer's disease brains, consist of insoluble
amyloid fibrils that result from the aggregation of amyloid beta peptides. None of the few …

Amyloid is the term usually used to describe a particular type of elongated, unbranched
protein fibril with cross-β-sheet characteristics, formed through the ordered aggregation of …

Even though the accumulation of arginine and the deposit of aggregated Aβ-peptides
(senile plaques) in the brain of an Alzheimer patient are classic points of evidence in the …

A-type EGCG dimer is a new proanthocyanidins dimer from persimmon fruits. In the present
study, we firstly examined the effects of EGCG and A-type EGCG dimer on Aβ 40 …

A number of ligands with affinities for the heme binding site of apomyoglobin were tested to
control amorphous and fibrillar aggregation in the protein. Several techniques, including …

Aims: Biflavonoids have attracted attention of researchers over the last few decades due to
their pharmacological activities. Amentoflavone, a biflavonoid considered as apigenin dimer …

Silibinin is the main biologically active component of silymarin extract and consists of a
mixture 1: 1 of two diastereoisomeric flavonolignans, namely silybin A (1a) and silybin B …

Previous phytochemical investigations of Akebiae Caulis resulted in the isolation of
triterpenes, triterpene glycosides, phenylethanoid glycosides and megastigmane glycoside …