Biflavonoids are associated with a variety of biologically useful properties. However,
synthetic biflavonoids are poorly explored within drug discovery. There is considerable …

Direct inhibition of amyloid fibrillation, the primary cause of many neurodegenerative
diseases, using natural and synthetic molecules is one of the therapeutic strategies to …

Mitotic kinesin Eg5 remains a validated target in antimitotic therapy because of its essential
role in the formation and maintenance of bipolar mitotic spindles. Although numerous Eg5 …

The role of various structural features, namely basic scaffolds and substituents of small
molecule inhibitors of the self-assembly of amyloid-beta (Aβ) peptide, a key process in …

The β-amyloid peptide (1-42) is a molecule capable of aggregating into neurotoxic
structures that have been implicated as potential etiological factors of Alzheimer's Disease …

Alzheimer's disease (AD) is proposed to be induced by abnormal aggregation of amyloidβ in
the brain. Here, we designed a brain-permeable peptide nanofiber drug from a fragment of …

Backgrounds The process of amyloid proteins aggregation causes several human
neuropathologies. In some cases, eg. fibrillar deposits of insulin, the problems are …

Dehydroabietylamine derivatives have been reported to eliminate the superoxide anion
(O2−˙) and 1, 1-dipheny-2-picrylhydrazyl radicals. In this work, several dehydroabietylamine …